128372-78-1

Basic information

• Product Name: (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone
• CAS NO: 128372-78-1
• Molecular Weight: 261.321
• Mol File: 128372-78-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone(128372-78-1)
• EPA Substance Registry System: (+)-(R)-1-tert-Butoxycarbonyl-4-phenyl-2-pyrrolidinone(128372-78-1)

Safety Data

• Hazardous Substances Data: 128372-78-1(Hazardous Substances Data)

Upstream product

• 928215-96-7 2-oxo-4-phenyl-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 141293-14-3 N-(tert-butoxycarbonyl)pyrrol-2(5H)-one 
• 98-80-6 phenylboronic acid 
• 143-66-8 sodium tetraphenyl borate 
• 138782-42-0 (3R,4R)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 
• 52450-32-5 Ethyl (E)-2-oxo-4-phenylpyrrolidine-3-carboxylate 
• 67159-52-8 (3R*,4S*)-2-oxo-4-phenyl-pyrrolidine-3-carboxylic acid 
• 5292-53-5 diethyl benzalmalonate 
• 185067-05-4 ethyl 2-carbethoxy-3-cyano-3-phenylpropionate 
• 145549-03-7 (3S,7R,7aR)-3,7-Diphenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 591-51-5 phenyllithium 
• 24424-99-5 di-tert-butyl dicarbonate 
• 71657-88-0 (4R)-4-phenyl-2-pyrrolidone 
• 138812-85-8 (3S,4S)-N-<(1R)-2-Hydroxy-1-phenylethyl>-2-oxo-4-phenylpyrrolidine-3-carboxamide 

Downstream Products

• 26250-90-8 (R)-3-tert-butyloxycarbonyl-β²-homophenylalanine 
• 26250-90-8 (S)-2-[(tert-butoxycarbonylamino)methyl]-3-phenylpropanoic acid 
• 220117-36-2 methyl 2-benzyl-3-(tert-butoxycarbonylamino)propanoate 

Relevant articles and documents

Highly Enantioselective Synthesis of Chiral γ-Lactams by Rh-Catalyzed Asymmetric Hydrogenation

A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α,β-unsaturated lactams bearing a β-aryl or β-alkyl substituent were smoothly hydrogenated to

Asymmetric synthesis of β-substituted γ-lactams via rhodium/diene-catalyzed 1,4-additions: Application to the synthesis of (R)-baclofen and (R)-rolipram

An efficient rhodium/diene-catalyzed asymmetric addition of arylboronic acids to α,β-unsaturated γ-lactams has been developed. The power of this methodology is further demonstrated by the concise synthesis of (R)-baclofen and (R)-rolipram.

Resolution of 4-phenyl-2-pyrrolidinone: A versatile synthetic intermediate

A resolution of 4-phenyl-2-pyrrolidinone is described. The resulting enantiomerically pure pyrrolidinones are exploited as precursor to 3-phenylpyrrolidines and 3-phenyl-γ-amino acids (4-amino-3-phenylbutanoic acid derivatives).