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Product FOB Price Min.Order Supply Ability Supplier
(2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE
Cas No: 128446-35-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
Cas No: 128446-35-5
No Data 1 Kilogram 110 Kilogram/Week Career Henan Chemical Co Contact Supplier
High purity Various Specifications Hydroxypropyl-beta-cyclodextrin CAS:128446-35-5
Cas No: 128446-35-5
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
CAS:128446-35-5 Hydroxypropyl-beta-cyclodextrin
Cas No: 128446-35-5
No Data 1 Kilogram 100 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
High quality Hydroxypropyl-Beta-Cyclodextrin supplier in China
Cas No: 128446-35-5
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
Cas No: 128446-35-5
USD $ 0.9-1.0 / Kilogram 1 Kilogram 1000 Kilogram/Month LIDE PHARMACEUTICALS LIMITED Contact Supplier
Hydroxypropyl Beta Cyclodextrin 98% CAS NO.128446-35-5
Cas No: 128446-35-5
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High quality (2-Hydroxypropyl)-beta-cyclodextrin Cas 128446-35-5 with reasonable price
Cas No: 128446-35-5
USD $ 27.0-30.0 / Kilogram 25 Kilogram 100 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Stabilizer emulsifier odor absorber Hydroxypropyl Beta Cyclodextrin HPCD
Cas No: 128446-35-5
USD $ 37.0-45.0 / Kilogram 500 Kilogram 100000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Hydroxypropyl-β-cyclodextrin
Cas No: 128446-35-5
No Data 100 Gram 20 Metric Ton/Week Henan Allgreen Chemical Co.,Ltd Contact Supplier

128446-35-5 Usage

Production Methods

Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.

Safety

The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.

Regulatory Status

Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

Uses

enteric coating, sustained release formulations, buccal and transdermal drug delivery

Chemical Properties

White to slightly yellow powder

Uses

2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis

Chemical Properties

Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

storage

Store in well-closed containers.

Pharmaceutical Applications

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations. Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

Uses

2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.

128446-35-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (H0979)  Hydroxypropyl-β-cyclodextrin   128446-35-5 25g 870.00CNY Detail
TCI America (H0979)  Hydroxypropyl-β-cyclodextrin   128446-35-5 100g 1,810.00CNY Detail
Alfa Aesar (H31133)  (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480    128446-35-5 5g 424.0CNY Detail
Alfa Aesar (H31133)  (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480    128446-35-5 25g 1297.0CNY Detail
Alfa Aesar (H31133)  (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480    128446-35-5 100g 3674.0CNY Detail
Sigma-Aldrich (Y0000186)  Hydroxypropylbetadex  European Pharmacopoeia (EP) Reference Standard 128446-35-5 Y0000186 1,880.19CNY Detail
USP (1329709)  Hydroxypropylbetadex  United States Pharmacopeia (USP) Reference Standard 128446-35-5 1329709-200MG 4,588.74CNY Detail
Aldrich (332593)  (2-Hydroxypropyl)-β-cyclodextrin  average Mw ~1,380 128446-35-5 332593-5G 577.98CNY Detail
Aldrich (332593)  (2-Hydroxypropyl)-β-cyclodextrin  average Mw ~1,380 128446-35-5 332593-25G 1,770.21CNY Detail
Aldrich (332593)  (2-Hydroxypropyl)-β-cyclodextrin  average Mw ~1,380 128446-35-5 332593-100G 4,986.54CNY Detail
Aldrich (332607)  (2-Hydroxypropyl)-β-cyclodextrin  average Mw ~1,460 128446-35-5 332607-5G 457.47CNY Detail
Aldrich (332607)  (2-Hydroxypropyl)-β-cyclodextrin  average Mw ~1,460 128446-35-5 332607-25G 713.70CNY Detail

128446-35-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-Hydroxypropyl)-β-cyclodextrin

1.2 Other means of identification

Product number -
Other names Cal Red (1:100 diluted with KSO)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128446-35-5 SDS

128446-35-5Synthetic route

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C105H196O56*2C47H51NO14

C105H196O56*2C47H51NO14

Conditions
ConditionsYield
In ethanol at 30℃; for 24h;
ethylene glycol diglycidyl ether
2224-15-9

ethylene glycol diglycidyl ether

hydroxypropyl methylcellulose

hydroxypropyl methylcellulose

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

polymer, cross-linked; monomers: hydroxypropyl-β-cyclodextrin; hydroxypropylmethylcellulose; ethyleneglycol diglycidyl ether

polymer, cross-linked; monomers: hydroxypropyl-β-cyclodextrin; hydroxypropylmethylcellulose; ethyleneglycol diglycidyl ether

Conditions
ConditionsYield
In sodium hydroxide at 20 - 50℃;
heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C18H28N2O*C105H196O56*ClH

C18H28N2O*C105H196O56*ClH

Conditions
ConditionsYield
In water-d2
Tetramethylenedisulfotetramine
80-12-6

Tetramethylenedisulfotetramine

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C4H8N4O4S2*C105H196O56

C4H8N4O4S2*C105H196O56

Conditions
ConditionsYield
In water-d2 at 30℃;
heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

cilnidipine
132203-70-4

cilnidipine

C105H196O56*C27H28N2O7

C105H196O56*C27H28N2O7

Conditions
ConditionsYield
In water at 20℃; for 24h;
telmisatran
144701-48-4

telmisatran

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C33H30N4O2*C105H196O56

C33H30N4O2*C105H196O56

Conditions
ConditionsYield
In water at 37℃; for 24h; pH=10;
zaleplon
151319-34-5

zaleplon

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C105H196O56*C17H15N5O

C105H196O56*C17H15N5O

Conditions
ConditionsYield
In water-d2 at 21.84℃; Thermodynamic data;
heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
p-Octylphenol
1806-26-4

p-Octylphenol

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
4-Nonylphenol
104-40-5

4-Nonylphenol

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril
73963-72-1

6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

2C105H196O56*C20H27N5O2

2C105H196O56*C20H27N5O2

Conditions
ConditionsYield
In ethanol; water at 30℃;
curcumin
458-37-7

curcumin

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C21H20O6*2C105H196O56

C21H20O6*2C105H196O56

Conditions
ConditionsYield
In water at 20℃; for 12h;
amodiaquin
86-42-0

amodiaquin

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C105H196O56*C20H22ClN3O

C105H196O56*C20H22ClN3O

Conditions
ConditionsYield
In water at 29.84℃; for 48h;

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