128446-35-5

Basic information

• Product Name: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
• Synonyms: beta-cyclodextrin,2-hydroxypropylether;beta-hydroxypropylcyclodextrin;(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;(2-Hydroxypropyl)-β-cyclodextrin;2-Hydroxypropyl-B-Cyclodextrin ;2-HYDROXYPROPYL-B-CYCLODEXTRIN CELLCULTU RE TESTED;HYDROXYPROPYL-BETA-CYCLODEXTRIN (MS = 0. 8);(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN (MS=1.0)
• CAS NO: 128446-35-5
• Molecular Formula: C₁₀₅H₁₉₆O₅₆
• Molecular Weight: 1541.54
• EINECS: 420-920-1
• Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Synthetic Reagents;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools;Carbohydrates & Derivatives;Other APIs
• Mol File: 128446-35-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 278 °C (dec.)
• Boiling Point: 400℃
• Appearance: White to slightly yellow/solution (clear, colorless)
• Density: 1.05 at 20.3℃
• Refractive Index: 125 ° (C=1, H2O)
• Storage Temp.: 2-8°C
• Solubility: H2O: 45 % (w/v)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN(128446-35-5)
• EPA Substance Registry System: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN(128446-35-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: GU2293332
• TSCA: Yes
• Hazardous Substances Data: 128446-35-5(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 128446-35-5 differently. You can refer to the following data:
1. White to slightly yellow powder
2. Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

Uses

Different sources of media describe the Uses of 128446-35-5 differently. You can refer to the following data:
1. 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
2. enteric coating, sustained release formulations, buccal and transdermal drug delivery
3. 2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis

Production Methods

Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.

General Description

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.

Pharmaceutical Applications

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations. Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

Safety

The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.

storage

Store in well-closed containers.

Regulatory Status

Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

Synthetic route

taxol (33069-62-4) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C105H196O56*2C47H51NO14

Conditions	Yield
In ethanol at 30℃; for 24h;

ethylene glycol diglycidyl ether (2224-15-9) + hydroxypropyl methylcellulose + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → polymer, cross-linked; monomers: hydroxypropyl-β-cyclodextrin; hydroxypropylmethylcellulose; ethyleneglycol diglycidyl ether

Conditions	Yield
In sodium hydroxide at 20 - 50℃;

bupivacaine hydrochloride (14252-80-3, 15233-43-9, 18010-40-7, 27262-46-0, 27262-48-2) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C18H28N2O*C105H196O56*ClH

Conditions	Yield
In water-d2

Tetramethylenedisulfotetramine (80-12-6) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C4H8N4O4S2*C105H196O56

Conditions	Yield
In water-d2 at 30℃;

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) + cilnidipine (132203-70-4) → C105H196O56*C27H28N2O7

Conditions	Yield
In water at 20℃; for 24h;

telmisatran (144701-48-4) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C33H30N4O2*C105H196O56

Conditions	Yield
In water at 37℃; for 24h; pH=10;

zaleplon (151319-34-5) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C105H196O56*C17H15N5O

Conditions	Yield
In water-d2 at 21.84℃; Thermodynamic data;

BPA (80-05-7) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → (2-hydroxypropyl)-β-cyclodextrin

Conditions	Yield
With hydrogenchloride In water at 20℃;

p-Octylphenol (1806-26-4) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → (2-hydroxypropyl)-β-cyclodextrin

Conditions	Yield
With hydrogenchloride In water at 20℃;

4-Nonylphenol (104-40-5) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → (2-hydroxypropyl)-β-cyclodextrin

Conditions	Yield
With hydrogenchloride In water at 20℃;

6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril (73963-72-1) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → 2C105H196O56*C20H27N5O2

Conditions	Yield
In ethanol; water at 30℃;

curcumin (458-37-7) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C21H20O6*2C105H196O56

Conditions	Yield
In water at 20℃; for 12h;

amodiaquin (86-42-0) + heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin (128446-35-5) → C105H196O56*C20H22ClN3O

Conditions	Yield
In water at 29.84℃; for 48h;