128540-55-6

Upstream product

• 143-33-9 sodium cyanide 
• 128540-54-5 ((R)-2-Cyclohexyl-1-formyl-ethyl)-carbamic acid isopropyl ester 
• 108-24-7 acetic anhydride 
• 128540-54-5 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 124947-31-5 N-(isopropoxycarbonyl)-L-phenylalanine methyl ester 
• 124995-02-4 (S)-N-(isopropoxycarbonyl)phenylalaninol 
• 128540-53-4 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 
• 63-91-2 L-phenylalanine 

Downstream Products

• 113785-82-3 (3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride 
• 121506-22-7 (2R,3S)-nor-C-statine hydrochloride 
• 140409-01-4 (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride 

Relevant academic research and scientific papers

A Practical Synthesis of threo-3-Amino-2-hydroxycarboxylic Acids

An expeditious synthesis of (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid (2) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (4), the key components of the renin inhibitor (1) and bestatin (3), respectively, have been accomplished by featuring hi

An Expeditions Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxy-carboxylic Acids, the Key Components of a Renin Inhibitor and Bestatin, from (S)- and (R)-Phenylalanine

The title synthesis could be achieved by featuring highly diastereoselective formation of a cyanohydrin acetate from an aldehyde under the phase-transfer conditions.