128625-50-3

Upstream product

• 36850-80-3 [(1-methoxyvinyl)oxy]trimethylsilane 
• 128540-54-5 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 
• 63-91-2 L-phenylalanine 
• 128540-53-4 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 
• 124995-02-4 (S)-N-(isopropoxycarbonyl)phenylalaninol 
• 124947-31-5 N-(isopropoxycarbonyl)-L-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 138448-74-5 methyl <(4S,5R)-4-cyclohexylmethyl-2,2-dimethyl-3-isopropoxycarbonyl-1,3-oxazolidin-5-yl>acetate 
• 105192-90-3 ACHPA 

Relevant academic research and scientific papers

A highly stereoselective synthesis of (3S,4S)-statine and (3S,4S)-cyclohexylstatine

The title compounds, which are synthetic intermediates of renin inhibitors, could be prepared from (S)-leucine and (S)-phenylalanine, respectively, by employing highly stereoselective aldol reactions of O-methyl-O-trimethylsilyl ketene acetal with an (S)-

An expeditious synthesis of (3S,4S)-statine and (3S,4S)cyclohexylstatine

The title synthesis could be accomplished by employing highly stereoselective aldol reaction of O-methyl-O-trimethylsilyl ketene acetal with the (S)-α-amido aldehyde (2) in the presence of titanium (IV) chloride as a key step.