128773-72-8Relevant articles and documents
An easily assembled highly active ruthenium initiator for olefin metathesis
Buschmann, Nicole,Wakamatsu, Hideaki,Blechert, Siegfried
, p. 667 - 670 (2004)
A practical and easily assembled synthesis of new ruthenium alkylidene precatalyst 8 is described, which exhibits excellent metathesis activity in ring-closing and ring-opening cross metathesis processes.
A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine
Almehmadi, Yaseen A.,Dixon, Darren J.,Gabriel, Pablo,Wong, Zeng Rong
supporting information, p. 10828 - 10835 (2021/07/31)
A new reductive strategy for the stereo- and regioselective synthesis of functionalized isoquinuclidines has been developed. Pivoting on the chemoselective iridium(I)-catalyzed reductive activation of β,γ-unsaturated δ-lactams, the efficiently produced reactive dienamine intermediates readily undergo [4 + 2] cycloaddition reactions with a wide range of dienophiles, resulting in the formation of bridged bicyclic amine products. This new synthetic approach was extended to aliphatic starting materials, resulting in the efficient formation of cyclohexenamine products, and readily applied as the key step in the shortest (five-step) total synthesis of vinca alkaloid catharanthine to date, proceeding via its elusive biosynthetic precursor, dehydrosecodine.
Preparation of aα,β-Unsaturated Lactams through intramolecular electrophilic carbamoylation of Alkenes
Yasui, Yoshizumi,Kakinokihara, Issei,Takeda, Hiroshi,Takemoto, Yoshiji
experimental part, p. 3989 - 3993 (2010/03/24)
A general, synthetic method for the preparation of α, βunsaturated lactams startingsei from alkenylchloroformamides has been developed. The reaction was complete within five minutes at 150 °C in N-methylpyrrolidone with a catalytic amount of HBr under mic
