1287764-86-6Relevant academic research and scientific papers
EGFR/HER-2 inhibitors: Synthesis, biological evaluation and 3D-QSAR analysis of dihydropyridine-containing thiazolinone derivatives
Ren, Yu-Jia,Wang, Zhong-Chang,Zhang, Xin,Qiu, Han-Yue,Wang, Peng-Fei,Gong, Hai-Bin,Jiang, Ai-Qin,Zhu, Hai-Liang
, p. 21445 - 21454 (2015/03/30)
A series of dihydropyridine containing thiazolinone derivatives (4a-4r) have been designed, synthesized and their biological activities evaluated as potential EGFR and HER-2 kinase inhibitors and in tumor cell antiproliferation. The synthesized compounds
Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines
Ciupa, Alexander,De Bank, Paul A.,Mahon, Mary F.,Wood, Pauline J.,Caggiano, Lorenzo
, p. 956 - 961 (2013/07/27)
The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)- pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.
Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives
Wang, Shuxiang,Shao, Wenqing,Li, Hongdong,Liu, Cui,Wang, Ke,Zhang, Jinchao
experimental part, p. 1914 - 1918 (2011/05/04)
Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5- dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV, 1H NMR, 13C NMR, MS, and thermal analysis
