128811-37-0

Basic information

• Product Name: tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate
• Synonyms: tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate;Boc-D-PyroglutaMinol;2-Methyl-2-propanyl (2R)-2-(hydroxyMethyl)-5-oxo-1-pyrrolidinecarboxylate;(R)-tert-Butyl 2-(hydroxyMethyl)-5-oxopyrrolidine-1-carboxylate;(R)-1-Boc-2-(hydroxymethyl)-5-oxopyrrolidine
• CAS NO: 128811-37-0
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.247
• Mol File: 128811-37-0.mol

Chemical Properties

• Boiling Point: 370.861 °C at 760 mmHg
• Flash Point: 178.09 °C
• Appearance: /
• Density: 1.182
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate(128811-37-0)
• EPA Substance Registry System: tert-Butyl (2R)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate(128811-37-0)

Safety Data

• Hazardous Substances Data: 128811-37-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 64700-65-8 methyl (2R)-pyroglutamate 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 128899-30-9 (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one 
• 6893-26-1 D-Glutamic acid 
• 141293-21-2 (1'S,4''R,5R)-1-(tert-butoxycarbonyl)-5-[(2,2-dimethyl-1,3-dioxolan-4-yl)hydroxymethyl]pyrrolidin-2-one 
• 141293-15-4 (1'S,2R,4''R)-2-[(2,2-dimethyl-[1,3]dioxolan-4-yl)hydroxymethyl]-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylic acid tert-butyl ester 
• 141293-28-9 N-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyl)oxy]pyrrole 
• 141293-14-3 N-(tert-butoxycarbonyl)pyrrol-2(5H)-one 
• 185303-67-7 (R)-N-(tert-butoxycarbonyl)-5-formylpyrrolidin-2-one 
• 128811-31-4 tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate 

Downstream Products

• 128811-31-4 tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate 
• 494221-65-7 (5S)-7-((2R)-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl}-5-oxopyrrolidin-1-yl)-5-methylheptanoic acid 
• 494221-68-0 (5R)-7-((2R)-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl}-5-oxopyrrolidin-1-yl)-5-methylheptanoic acid 
• 494221-67-9 4-{1-[2-((2R)-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl}-5-oxopyrrolidin-1-yl)ethyl]cyclopropyl}butanoic acid 
• 1369917-84-9 C₂₅H₃₇NO₅ 
• 1369917-62-3 tert-butyl (2R)-2-{(1E)-4-[3-(methoxymethyl)phenyl]-3-oxo-1-buten-1-yl}-5-oxo-1-pyrrolidinecarboxylate 
• 1369917-64-5 tert-butyl (2R)-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinecarboxylate 
• 1369917-65-6 (5R)-5-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-2-pyrrolidinone 
• 1369917-72-5 methyl (5S)-7-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]-5-methylheptanoate 
• 1369917-74-7 methyl (5R)-7-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]-5-methylheptanoate 
• 1369917-75-8 methyl 4-(1-{2-[(2R)-2-{(1E,3S)-3-(tert-butyldimethylsilyloxy)-4-[3-(methoxymethyl)phenyl]-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]ethyl}cyclopropyl)butanoate 
• 128811-44-9 tert-butyl N-<(1R)-1-<<(4-methylphenyl)sulfonyloxy>methyl>-4-oxo-4-phenylbutyl>carbamate 
• 128811-45-0 tert-butyl N-<(1R)-1-<(methylsulfonyloxy)methyl>-4-oxo-4-phenylbutyl>carbamate 
• 128811-42-7 (R)-2-benzyl-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

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Starting from D-glutamic acid (5), the bicyclic compounds 4a and 4b were synthesized via 17 (Schemes 1 and 2).The reaction leading to 4g and 4h with LiCuPh2 was not successful.But treatment of the N-protected model lactams 19, 21, and 22 with Li2Cu(CN)Ph2 gave the amino ketones 24, 26, and 26, respectively (Scheme 3).The desired compound 23 was obtained from 20.Conversion of the unprotected lactams 28, 31, and 32 gave the phenyl derivative 34 in excellent yields.Ester 35 was transformed to the α-amino-γ-oxo-acid derivative 36.This conversion opens a novel access to this type of compounds.