128915-56-0

Basic information

• Product Name: N-DesMethyl Asenapine-d4
• Synonyms: N-DesMethyl Asenapine-d4;N-DesMethyl Asenapine HCl;N-Desmethylasenapine
• CAS NO: 128915-56-0
• Molecular Formula: C₁₆H₁₄ClNO
• Molecular Weight: 271.74146
• Mol File: 128915-56-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-DesMethyl Asenapine-d4(CAS DataBase Reference)
• NIST Chemistry Reference: N-DesMethyl Asenapine-d4(128915-56-0)
• EPA Substance Registry System: N-DesMethyl Asenapine-d4(128915-56-0)

Safety Data

• Hazardous Substances Data: 128915-56-0(Hazardous Substances Data)

Usage

Uses

N-Desmethyl Asenapine is a metabolite of Asenapine that is used as an atypical antipsychotic for the treatment of schizophrenia and acute mania associated with bipolar disorder.

Upstream product

• 70958-20-2 5-chloro-2-phenoxyphenylacetic acid 
• 70958-18-8 5-chloro-2-phenoxyacetophenone 
• 912356-02-6 8-chloro-dibenz[b,f]oxepin-10-carboxylic acid methyl ester 
• 1141493-78-8 (5-chloro-2-phenoxy-phenyl)-acetic acid methyl ester 
• 912356-01-5 (E and Z)-2-(5-chloro-2-phenoxy-phenyl)-3-hydroxy-acrylic acid methyl ester 
• 108-95-2 phenol 
• 2476-37-1 2,5-dichloroacetophenone 
• 65576-45-6 asenapine 
• 85650-56-2 trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate 

Downstream Products

• 1391745-10-0 [(13)CD3]-2-((3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro1-H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol 
• 1217729-73-1 [(13)CD3]-asenapine 
• 65576-45-6 asenapine 

Relevant articles and documents

Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole

This invention provides improved processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole, asenapine. These processes allow the preparation of asenapine at industrial scale in good yields and high stereoselectivity.

Biotransformation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate in rats

The metabolism of trans-5-chloro-2-methyl-2,3,3a-12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate (Org 5222) labelled with [3H] or [14C] was investigated in Wistar rats. Metabolites were identified by mass spectrometry, 13C- and 1H-NMR analysis, IR spectroscopy and, wherever possible, by comparison with authentic reference compounds. The metabolites found in plasma, bile, faeces and urine revealed the processes of metabolism in which Org 5222 underwent oxidation to yield an N-oxide existing in two diastereoisomeric forms, or N-demethylation to yield a demethyl metabolite. A novel metabolite was found in bile viz. a carbamate glucuronide, formed from an intermediate carbamic acid, derived from the addition of CO2 to the demethyl metabolite.