70958-18-8

Basic information

• Product Name: 1-(5-chloro-2-phenoxyphenyl)ethanone
• Synonyms: 1-(5-chloro-2-phenoxyphenyl)ethanone;Ethanone, 1-(5-chloro-2-phenoxyphenyl)-;5-chloro-2-phenoxyacetophenone
• CAS NO: 70958-18-8
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.68894
• EINECS: 604-604-1
• Mol File: 70958-18-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 58-59℃ (methanol )
• Boiling Point: 349°C at 760 mmHg
• Flash Point: 140.5°C
• Appearance: /
• Density: 1.212±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 4.85E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 1-(5-chloro-2-phenoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-chloro-2-phenoxyphenyl)ethanone(70958-18-8)
• EPA Substance Registry System: 1-(5-chloro-2-phenoxyphenyl)ethanone(70958-18-8)

Safety Data

• Hazardous Substances Data: 70958-18-8(Hazardous Substances Data)

Usage

General Description

1-(5-chloro-2-phenoxyphenyl)ethanone is a chemical compound with the molecular formula C14H10ClO2. It is a yellowish crystalline solid that is commonly used as a building block in the synthesis of various organic compounds. This chemical is an aromatic ketone that contains a chlorine atom and a phenoxy group attached to a phenyl ring. It is often used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. 1-(5-chloro-2-phenoxyphenyl)ethanone is known for its ability to undergo various chemical reactions, and its structure makes it a versatile starting material for the synthesis of a wide range of organic compounds.

InChI:InChI=1/C14H11ClO2/c1-10(16)13-9-11(15)7-8-14(13)17-12-5-3-2-4-6-12/h2-9H,1H3

Upstream product

• 2476-37-1 2,5-dichloroacetophenone 
• 12775-96-1 copper 
• 108-95-2 phenol 
• 139-02-6 sodium phenoxide 

Downstream Products

• 128915-56-0 trans-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrole 
• 1170701-78-6 trans-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride 
• 85650-56-2 trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate 
• 912356-01-5 (E and Z)-2-(5-chloro-2-phenoxy-phenyl)-3-hydroxy-acrylic acid methyl ester 
• 1141493-78-8 (5-chloro-2-phenoxy-phenyl)-acetic acid methyl ester 
• 70958-19-9 4-[2-(5-chloro-2-phenoxyphenyl)-1-thioxoethyl]morpholine 
• 55595-54-5 2-chloro-10,11-dihydrodibenzoxepin-10-one 
• 70958-20-2 5-chloro-2-phenoxyphenylacetic acid 

Relevant articles and documents

Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole

This invention provides improved processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole, asenapine. These processes allow the preparation of asenapine at industrial scale in good yields and high stereoselectivity.

Affinity of 10-(4-Methylpiperazino)dibenzoxepins for Clozapine and Spiroperidol Binding Sites in Rat Brain

10-(4-Methylpiperazino)dibenzoxepins were prepared and evaluated as potential antipsychotic agents using specific clozapine diazepine> binding sites in rat forebrain that are noncholinergic and nondopaminergic in nature and from which clozapine is displaced by known antipsychotic agents. Clozapine binding in the presence of atropine represents nonmuscarinic binding, while binding in the absence of atropine represents muscarinic (cholinergic) plus nonmuscarinic binding.The relative affinity for dopamine binding sites was determined by displacement of spiroperidol from binding sites in rat caudate nuclei.Thus, clozapine, its 2-chloro isomer, its dechloro analogue, and their 5H-dibenzocycloheptene and dibenzoxepin analogues have about the same relative affinity for the nonmuscarinic clozapine binding sites.At the spiroperidol (dopaminergic) sites, both the nature of the tricyclic system and the presence of chlorine atom on the tricyclic system have a substantial effect on the binding affinity.Within each series, shift of a chlorine atom from the position distal to the piperazino group to the proximal position increases the binding affinity by a factor of about nine, but removal of the chlorine atom substantially decreases the binding affinity.Nevertheless, 10-(4-methylpiperazino)dibenzoxepin has a threefold greater affinity for the dopaminergic binding sites than does clozapine itself.