128946-46-3

Upstream product

• 100428-41-9 2(S)-<(tert-butyldiphenylsilyl)oxy>-4(Z)-decenal 
• 136693-12-4 (8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-8,10,14-trien-6-methyl ynoate 
• 89682-45-1 (6E,8Z)-10-Bromo-5-(tert-butyl-diphenyl-silanyloxy)-deca-6,8-dienoic acid methyl ester 
• 90473-55-5 [(2Z,4E)-6-(tert-Butyl-diphenyl-silanyloxy)-9-methoxycarbonyl-nona-2,4-dienyl]-triphenyl-phosphonium; bromide 
• 90108-36-4 (6E,8Z,10E,14Z)-(S)-5,12-Bis-(tert-butyl-diphenyl-silanyloxy)-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 186581-53-3 diazomethane 
• 70578-51-7 (6E,8Z,10E,14Z)-(S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid 
• 71160-24-2 Leukotriene B 

Relevant academic research and scientific papers

An efficient synthesis of leukotriene B4

Leukotriene B4 (5S, 12R) and its epimer (5R, 12R) have been prepared by coupling a chiral hydroxy vinyl borane with a racemic vinyl iodide, followed by the easy separation of the thus formed diastereomers.

Total synthesis of (+)-leukotriene B4 methyl ester and its 5-epimer from (R)-glycidol

The Pd-Cu coupling reaction of a chiral hydroxy-(E,E)-iododiene with a racemic acetylenic alcohol followed by reduction of the dienyne leads to the desired (Z,E,E) geometry and allows synthesis of LTB4 and its 5-epimer after separation of diast

SYNTHESIS OF 5S,12S-diHETE (LTBx)

The total synthesis of 5S,12S-diHETE (LTBx) was completed.The Wittig reaction of phosphorane 8 and chiral aldehyde 9 provided the key step to form the C-20 chain.