An efficient synthesis of leukotriene B4

DOI: 10.1016/S0040-4039(01)93886-9

Source and publish data:

Tetrahedron Letters p. 6335 - 6336 (1989)

Update date:2022-08-11

Topics:

Authors:

Avignon-Tropis

Treilhou

Lebreton

Pougny Pougny

Frechard-Ortuno

Huynh Huynh

Linstrumelle

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Article abstract of DOI:10.1016/S0040-4039(01)93886-9

Leukotriene B₄ (5S, 12R) and its epimer (5R, 12R) have been prepared by coupling a chiral hydroxy vinyl borane with a racemic vinyl iodide, followed by the easy separation of the thus formed diastereomers.

Full text of DOI:10.1016/S0040-4039(01)93886-9

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Product name:(6E,8Z,10Z,14Z)-(5R,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid methyl ester

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