129058-50-0Relevant academic research and scientific papers
A new synthesis of dehydroluciferin [2-(6′-hydroxy-2′- benzothiazolyl)-thiazole-4-carboxylic acid] from 1,4-benzoquinone
Ciuffreda, Pierangela,Casati, Silvana,Meroni, Giuseppe,Santaniello, Enzo
, p. 5893 - 5897 (2013)
A new synthesis of dehydroluciferin [2-(6′-hydroxy-2′- benzothiazolyl)-thiazole-4-carboxylic acid], the oxidative product of luciferin, has been realized starting from 1,4-benzoquinone. Reaction of this compound with l-cysteine ethyl ester, followed by an oxidation-cyclization step afforded 2-carbethoxy-6-hydroxybenzothiazole that was in situ hydrolyzed and decarboxylated to 6-hydroxybenzothiazole. The tert-butyl(dimethyl)silyl ether of this key intermediate was subjected to α-lithiation followed by formylation with DMF, and the resulting aldehyde condensed with l-cysteine ethyl ester. Dehydrogenation of the intermediate thiazolidine followed by deprotection afforded dehydroluciferin in 35% overall yield from 1,4-benzoquinone (69% from 6-hydroxybenzothiazole).
Quaternary ammonium promoted ultra selective and sensitive fluorescence detection of fluoride ion in water and living cells
Li, Long,Ji, Yuzhuo,Tang, Xinjing
, p. 10006 - 10009 (2014)
Highly selective and sensitive fluorescent probes with a quaternary ammonium moiety have been rationally designed and developed for fast and sensitive fluorescence detection of fluoride ion (F- from NaF, not TBAF) in aqueous solution and living cells. With the sequestration effect of quaternary ammonium, the detection time was less than 2 min and the detection limit of fluoride ion was as low as 0.57 ppm that is among the lowest detection limits in aqueous solutions of many fluoride fluorescence probes in the literature.
A fluorescent probe for rapid aqueous fluoride detection and cell imaging
Ke, Bowen,Chen, Weixuan,Ni, Nanting,Cheng, Yunfeng,Dai, Chaofeng,Dinh, Hieu,Wang, Binghe
supporting information, p. 2494 - 2496 (2013/04/23)
A stable and highly selective fluorescent probe has been designed and synthesized for the rapid detection of fluoride ions (F-) in aqueous solution and living cells. The design was based on the high reactivity of F - toward a silyl g
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides
Borza, István,Bozó, éva,Barta-Szalai, Gizella,Kiss, Csilla,Tárkányi, Gábor,Demeter, ádám,Gáti, Tamás,Háda, Viktor,Kolok, Sándor,Gere, Anikó,Fodor, László,Nagy, József,Galgóczy, Kornél,Magdó, Ildikó,ágai, Béla,Fetter, József,Bertha, Ferenc,Keserü, Gy?rgy M.,Horváth, Csilla,Farkas, Sándor,Greiner, István,Domány, Gy?rgy
, p. 901 - 914 (2008/02/03)
(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structu
Synthesis of 6-Hydroxybenzothiazole-2-carboxylic Acid
Loewik, Dennis W. P. M.,Tisi, Lawrence C.,Murray, James A. H.,Lowe, Christopher R.
, p. 1780 - 1783 (2007/10/03)
The synthesis of 6-hydroxybenzothiazole-2-carboxylic acid (1) is presented. The benzothiazole ring was obtained by ring contraction of a remarkably stable 2-alkoxy-7-hydroxy-2H-benzo[1,4]thiazine intermediate that could be isolated. 6-Hydroxybenzothiazole
