884-22-0Relevant articles and documents
Method of synthesizing heteroaromatic formic ether compound
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Paragraph 0050, (2017/08/19)
The invention discloses a method of synthesizing a heteroaromatic formic ether compound. By taking midazolium chloride salt of which the molecular formula is [(ArN=C(CH3)NCH2CH2NCH2C6H5)CH]Cl (wherein Ar is equal to 2,6-bi-CH(CH3)2-C6H3) as a catalyst, the heteroaromatic formic ether compound is synthesized through carboxylation reaction of a heteroaromatic compound and carbon dioxide at atmospheric pressure. The heteroaromatic formic ether compound is a first example that is catalyzed by imidazolium salt and prepared through the carboxylation reaction of the heteroaromatic compound and carbon dioxide. Compared with the prior art, the catalyst is green, the synthesis is easier, reaction conditions are mild, and the heteroaromatic formic ether compound has equivalent or better catalytic activity and functional group tolerance.
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides
Borza, István,Bozó, éva,Barta-Szalai, Gizella,Kiss, Csilla,Tárkányi, Gábor,Demeter, ádám,Gáti, Tamás,Háda, Viktor,Kolok, Sándor,Gere, Anikó,Fodor, László,Nagy, József,Galgóczy, Kornél,Magdó, Ildikó,ágai, Béla,Fetter, József,Bertha, Ferenc,Keserü, Gy?rgy M.,Horváth, Csilla,Farkas, Sándor,Greiner, István,Domány, Gy?rgy
, p. 901 - 914 (2008/02/03)
(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structu
Synthesis of luciferin glycosides as substrates for novel ultrasensitive enzyme assays
Amess, Robert,Baggett, Neil,Darby, Paul R.,Goode, Anthony R.,Vickers, Ernest E.
, p. 225 - 233 (2007/10/02)
Condensation of 2-cyano-6-hydroxybenzothiazole with acetohalogeno derivatives of D-glucose, D-galactose, and 2-acetamido-2-deoxy-D-glucose gave the corresponding β-glycosides.Attempted basic deacetylation caused methanolysis of the nitrile group.Condensation of the first two acetylated glycosides with D-cysteine, followed by deacetylation, gave the firefly luciferin β-glycosides that were substrates for the corresponding glycohydrolases.The liberated luciferin was determined by fluorescence spectroscopy and, in one instance, by coupled-bioluminescence assay with firefly luciferase.The amount of luciferin released and determined by bioluminescence assay, was only ca. 65 percent of that determined by fluorescence spectroscopy, which suggested that the luciferin was partly racemised.Because of the great sensitivity of bioluminescence detection, these novel substrates provide potentially ultrasensitive assays for glycohydrolases, but their syntheses are more difficult than those of the corresponding fluorogenic substrates.
