129058-56-6

Basic information

• Product Name: 2-Benzothiazolecarboxylicacid,6-hydroxy-,methylester(9CI)
• Synonyms: 2-Benzothiazolecarboxylicacid,6-hydroxy-,methylester(9CI);Methyl 6-hydroxybenzothiazole-2-carboxylate;methyl 6-hydroxy-1,3-benzothiazole-2-carboxylate
• CAS NO: 129058-56-6
• Molecular Formula: C₉H₇NO₃S
• Molecular Weight: 209.23
• Product Categories: BENZOTHIAZOLE
• Mol File: 129058-56-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 200-206 °C
• Boiling Point: 371.4±34.0 °C(Predicted)
• Appearance: /
• Density: 1.467±0.06 g/cm3(Predicted)
• PKA: 7.78±0.40(Predicted)
• CAS DataBase Reference: 2-Benzothiazolecarboxylicacid,6-hydroxy-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolecarboxylicacid,6-hydroxy-,methylester(9CI)(129058-56-6)
• EPA Substance Registry System: 2-Benzothiazolecarboxylicacid,6-hydroxy-,methylester(9CI)(129058-56-6)

Safety Data

• Hazardous Substances Data: 129058-56-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 64-17-5 ethanol 
• 939-69-5 2-cyano-6-hydroxybenzothiazole 
• 943-03-3 2-cyano-6-methoxybenzothiazole 
• 946-13-4 6-methoxybenzo[d]thiazol-2-carboxylic acid 
• 884-22-0 6-methoxy-benzothiazole-2-carboxylic acid methyl ester 
• 389135-58-4 Methyl 2-methoxy-7-hydroxy-2H-benzo[1,4]thiazine-3-carboxylate 

Downstream Products

• 129058-50-0 6-hydroxybenzo[d]thiazole-2-carboxylic acid 
• 13599-84-3 6-hydroxybenzothiazole 

Relevant articles and documents

Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties

Five new firefly luciferin (1) analogues were synthesized and their light emission properties were examined. Modifications of the thiazoline moiety in 1 were employed to produce analogues containing acyclic amino acid side chains (2–4) and heterocyclic rings derived from amino acids (5 and 6) linked to the benzothiazole moiety. Although methyl esters of all of the synthetic derivatives exhibited chemiluminescence activity, only carboluciferin (6), possessing a pyrroline-substituted benzothiazole structure, had bioluminescence (BL) activity (λmax=547 nm). Results of bioluminescence studies with AMP-carboluciferin (AMP=adenosine monophosphate) and AMP-firefly luciferin showed that the nature of the thiazoline mimicking moiety affected the adenylation step of the luciferin–luciferase reaction required for production of potent BL. In addition, BL of 6 in living mice differed from that of 1 in that its luminescence decay rate was slower.

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides

(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structu

Signalling compounds for use in methods of detecting hydrogen peroxide

Compounds useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: is reacted with peroxide. Sig is an aromatic or heteroaromatic ring group, B is a boron atom, and R5 and R6 are independently selected from hydrogen and lower alkyl groups and can be joined together as a straight or branched alkylene chain forming a five or six-membered ring. A detectable product compound of the formula Sig-OH Is produced and detected by measuring color, fluorescence, chemiluminescence, or bioluminescence. The signalling compound itself does not possess the detectable property or does so only to a very weak degree. The compounds can be used for detection in assays for peroxide or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.