1292836-16-8

Usage

Uses

Used in Organic Synthesis:
1-(4-Chloro-2-fluoro-5-nitro-phenyl)-ethanone is used as a key intermediate in organic synthesis for the creation of complex organic molecules. Its reactivity and functional groups facilitate various chemical reactions, making it a versatile component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4-Chloro-2-fluoro-5-nitro-phenyl)-ethanone is used as a building block for the development of new drugs. Its unique structure allows for the design of novel therapeutic agents with potential applications in treating various diseases and conditions.
Used in Agrochemical Development:
1-(4-Chloro-2-fluoro-5-nitro-phenyl)-ethanone is also utilized in the development of agrochemicals, where its reactivity and functional groups can be leveraged to create new compounds with pesticidal or herbicidal properties, contributing to advancements in crop protection and agricultural productivity.

Upstream product

• 351-28-0 N-(3-fluorophenyl)acetamide 
• 372-19-0 meta-fluoroaniline 
• 175711-83-8 4’-chloro-2’-fluoroacetophenone 
• 35112-05-1 4-chloro-2-fluoro-5-nitro-benzoic acid 
• 947311-91-3 4-chloro-2-fluoro-5-nitro-benzoyl chloride 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1890114-11-0 (2S,2'S)-di-tert-butyl 2,2'-(6,6'-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-1H-benzo[d]imidazole-6,2-diyl))bis(pyrrolidine-1-carboxylate) 
• 1332357-14-8 (S)-6,6'-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-2-((S)pyrrolidin-2-yl)-1hbenzo[d]imidazole) 

Relevant academic research and scientific papers

Preparation method of 4-chloro-2-fluoro-5-nitroacetophenone

The invention discloses a preparation method of 4-chloro-2-fluoro-5-nitroacetophenone, the preparation method is characterized in that m-fluoroaniline is taken as an initial raw material, and the 4-chloro-2-fluoro-5-nitroacetophenone is obtained through acetylation amino protection, Friedel-Crafts acylation reaction, hydrolysis reaction, Sandmeyer reaction and final nitration, and the preparationmethod has the advantages of easily available raw materials, low reaction condition requirement, few side reactions and high yield.

Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Curative interferon and ribavirin sparing treatments for hepatitis C virus (HCV)-infected patients require a combination of mechanistically orthogonal direct acting antivirals. A shared component of these treatments is usually an HCV NS5A inhibitor. First generation FDA approved treatments, including the component NS5A inhibitors, do not exhibit equivalent efficacy against HCV virus genotypes 1-6. In particular, these first generation NS5A inhibitors tend to select for viral drug resistance. Ombitasvir is a first generation HCV NS5A inhibitor included as a key component of Viekira Pak for the treatment of patients with HCV genotype 1 infection. Since the launch of next generation HCV treatments, functional cure for genotype 1-6 HCV infections has been achieved, as well as shortened treatment duration across a wider spectrum of genotypes. In this paper, we show how we have modified the anchor, linker, and end-cap architecture of our NS5A inhibitor design template to discover a next generation NS5A inhibitor pibrentasvir (ABT-530), which exhibits potent inhibition of the replication of wild-type genotype 1-6 HCV replicons, as well as improved activity against replicon variants demonstrating resistance against first generation NS5A inhibitors.