129354-36-5

Usage

Main properties

Chemical compound
Potential biological properties
Synthetic derivative of oligomycin A
Potential use in cancer therapy
Ability to disrupt cellular respiration
Ability to induce apoptosis in cancer cells
Potential as an antibacterial and antifungal agent

Also known as

Dimethyloligomycin A

Derived from

Oligomycin A

Mechanism of action

inhibition of ATP synthase enzyme in mitochondria

Potential applications

cancer therapy, antibacterial agent, antifungal agent

Need for further research

to fully understand therapeutic applications and mechanisms of action

Upstream product

• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 126-81-8 dimedone 
• 123-11-5 4-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 3471-13-4 dimedone 
• 675-10-5 4-hydroxy-6-methyl-2-pyron 

Downstream Products

• 761357-05-5 4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile 
• 1229931-89-8 2-(4-chlorophenylamino)-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxoquinoline-3-carbonitrile 
• 1229931-83-2 4-(4-methoxyphenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-2-(phenylamino)quinoline-3-carbonitrile 
• 1229932-02-8 2-(cyclohexylamino)-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxoquinoline-3-carbonitrile 
• 1610831-47-4 ethyl 2-cyano-3-(4-methoxyphenyl)-6,6-dimethyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-carboxylate 
• 1610831-50-9 2-cyano-3-(4-methoxyphenyl)-6,6-dimethyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-carboxamide 
• 1394250-80-6 4-(4-methoxy-phenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of some new chromeno[2,3-b]pyridine and [1,2,4]Triazolo[1,5-a]quinoline nucleoside analogues with expected biological activity

Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-4H-chromene-3- carbonitrile (2) and 1,2-diamino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile (11) which were utilized as starti

Eco-friendly, one-pot multicomponent synthesis of pyran annulated heterocyclic scaffolds at room temperature using ammonium or sodium formate as non-toxic catalyst

A simple, facile, and convenient practical method for one-pot synthesis of pharmaceutically interesting diverse kind of pyran annulated heterocycles such as 4H-pyrano[3,2-c]coumarins, 4H-pyrano[3,2-c]-α-pyrones, 5,6,7,8-tetrahydro-5-oxo-4H-chromenes and b

Synthesis and antimicrobial activities of new S-nucleosides of chromeno[2,3-B[pyridine derivatives and C-nucleosides of [1,2,4]Triazolo[1,5- A[quinoline derivatives

Direct preparation of 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7- dimethyl-5-oxo-4H-chromene-3-carbonitrile 2 and 1,2-diamino-1,4,5,6,7,8- hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-3-quinolinecarbonitrile 11, which were utilized as starting

[Fe3O4@SiO2@(C3H6)2-(Imidazolium)2-Butyl][MnCl42-] as a novel nanomagnetic catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran derivatives

In this article a convenient method for the synthesis of tetrahydrobenzo[b]pyran derivatives using imidazolium-based ionic liquid-stabilized on magnetic nanoparticles [Fe3O4@SiO2@(C3H6)2-(Imidazolium)2-Butyl][MnCl42-] as a new heterogeneous cat

Solvent Selective Polyacrylonitrile Fiber as a Recyclable Catalyst for the Knoevenagel-Michael Reaction in Water

Heterogeneous catalysis is an important branch of sustainable chemistry. In this work, a series of polyacrylonitrile fiber (PANF) fiber catalysts (PANF-E, PANF-EDs, and PANF-D) with different catalytic micro-environments are developed and characterized by

WELPSA: A natural catalyst of alkali and alkaline earth metals for the facile synthesis of tetrahydrobenzo[b]pyrans and pyrano[2,3-d]pyrimidinones as inhibitors of SARS-CoV-2

Since 2019, the infection of SARS-CoV-2 has been spreading worldwide and caused potentially lethal health problems. In view of this, the present study explores the most commodious and environmentally benign synthetic protocol for the synthesis of tetrahyd

Composite of magnetic carbon quantum dot-supported ionic liquid and Cu-BDC (CCDC no. 687690) MOF: A triple catalytic composite for chemical transformations

A novel magnetic triple composite was synthesized through immobilization of DABCO-based ionic liquid on magnetic carbon quantum dot, followed by conjugation of the resultant compound with a copper-based metal-organic framework (CCDC no. 687690). The as-pr

An eco-friendly innovative halide and metal-free basic ionic liquid catalyzed synthesis of tetrahydrobenzo [b] pyran derivatives in aqueous media: A sustainable protocol

A novel imidazolium-based highly efficient, recoverable, and reusable basic ionic liquid [PEMIM][OH] was synthesized using a very simple approach. This ionic liquid was employed as a catalyst for the multicomponent synthesis of tetrahydrobenzo[b]pyran der

Metformin functionalized dendritic fibrous nanosilica (KCC-1-nPr-Met) as an innovative and green nanocatalyst for the efficient synthesis of tetrahydro-4H-chromene derivatives

An innovative nanocatalyst (KCC-1-nPr-Met) has been prepared from the covalent attachment of metformin on the channels and the pores of n-propyl amine functionalized dendritic fibrous nanosilica (DFNS) and used towards efficient, green, and high yield syn

Synthesis and X-ray crystal structures of polyfunctionalized 4H-chromene derivatives via tricomponent reaction with Knoevenagel adducts as intermediates in aqueous medium

Chromenes and their derivatives are an important class of compounds known for their biological properties. In this study, synthetic methodologies were described to obtain 4H-chromene derivatives. Two routes were investigated, the first being a bicomponent