2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Base Information

• Chemical Name: 2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
• CAS No.: 129354-36-5
• Molecular Formula: C19H20N2O3
• Molecular Weight: 324.379
• Mol file: 129354-36-5.mol

Synonyms:2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-5, 6, 7, 8-tetrahydro-7, 7-dimethyl-5-oxo-4H-chromene-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile;2-amino-7,7-dimethyl-4-(4-methoxy-phenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-Amino-4-(4-methoxy-phenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-amino-7,7-dimethyl-5-oxo-4-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-1-benzopyran-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-6,6,8,8-tetrahydro-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile;

Chemical Property of 2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

Chemical Property:

• PSA: 85.34000
• LogP: 3.84638

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

There total 7 articles about 2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + dimedone (126-81-8) + malononitrile (109-77-3) → 2-amino-3-cyano-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran (129354-36-5)

Guidance literature:

With (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol; In ethanol; at 20 ℃; for 0.0833333h;

DOI:10.2174/157017810790534011

Reference yield: 96.0%

2-(4-methoxyphenylmethylene)malononitrile (2826-26-8) + dimedone (126-81-8) → 2-amino-3-cyano-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran (129354-36-5)

Guidance literature:

In water; for 0.0666667h; microwave irradiation;

DOI:10.1080/00397910701572696

Reference yield: 96.0%

dimedone (126-81-8) + malononitrile (109-77-3) → 2-amino-3-cyano-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran (129354-36-5)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; In water; at 90 ℃; for 6h;

upstream raw materials:

2-(4-methoxyphenylmethylene)malononitrile

dimedone

4-methoxy-benzaldehyde

malononitrile

Downstream raw materials:

2-(4-chlorophenylamino)-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxoquinoline-3-carbonitrile

4-(4-methoxyphenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-2-(phenylamino)quinoline-3-carbonitrile

2-(cyclohexylamino)-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxoquinoline-3-carbonitrile

4-(4-methoxy-phenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carbonitrile