129354-39-8

Upstream product

• 107752-97-6 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 126-81-8 dimedone 
• 873-95-0 1-amino-5,5-dimethylcyclohexen-3-one 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 6311-45-1 Dimethyl-dihydroresorcinmonoimin 

Downstream Products

• 1161856-40-1 2-amino-4-phenyl-7,7-dimethyl-5-thioxo-5,6,7,8-tetrahydroquinoline-3-carbonitrile 
• 1070204-50-0 C₂₄H₂₇N₃O 

Relevant academic research and scientific papers

Ultrasound promotes one-pot synthesis of 1,4-dihydropyridine and imidazo[1,2-a]quinoline derivatives, catalyzed by ZnO nanoparticles

Ultrasonic irradiation is being considered not only as a green approach but also as a powerful technique for the synthesis of 1,4-dihydropyridine and imidazo[1,2-a]quinoline derivatives. It can be carried out by using multicomponent reaction of cyclic ena

One-pot synthesis of hexahydroquinolines via a four-component cyclocondensation under microwave irradiation in solvent free conditions: A green chemistry strategy

Four-component cyclocondensation of aromatic aldehydes, malononitrile, dimedone and ammonium acetate proceeds under microwave irradiation in solvent free conditions to give highly functionalized hexahydroquinolines in excellent yields.

In situ synthesis of SO3H supported Fe3O4?resorcinol-formaldehyde resin core/shell and its catalytic evaluation towards the synthesis of hexahydroquinoline derivatives in green conditions

A novel spherically shaped core?double-shell acidic nanocatalyst (Fe3O4?SiO2?RF-SO3H) [RF: Resorcinol-formaldehyde resin] was prepared in situ and completely characterized using X-ray diffraction, Fourier transform infrared spectroscopy, vibrating sample

Microwave-irradiated one-pot synthesis of quinoline derivatives catalyzed by triethylamine

Abstract: An efficient and swift microwave (MW)-mediated procedure for synthesis of 11 quinoline derivatives has been designed based on reaction between aromatic aldehydes, malononitrile, 5,5-dimethylcyclohexane-1,3-dione, and ammonium acetate at room tem

N-(3-silyl propyl) diethylene triamine N,N',N''-tri-sulfonic acid immobilized on Fe3-xTixO4 magnetic nanoparticles: A new recyclable heterogeneous nanocatalyst for the synthesis of hexahydroquinolines

In the present study, for the first time N-(3-silyl propyl) diethylene triamine N,N',N''-tri-sulfonic acid (SPDETATSA) was grafted on magnetic Fe3-xTixO4 nanoparticles. The structure of the resulted nanoparticles was chara

Three-component synthesis of 5-aryl-1,8-naphthyridine-3-carbonitriles

A procedure has been developed for the synthesis of highly functionalized 1,8-naphthyridines by three-component condensation of aromatic aldehydes with malononitrile dimer and enamino ketones.

Design, synthesis, molecular docking studies and antitubercular evaluation of hexahydroquinolin-2-yl benzamide derivatives

A new series of hexahydroquinolin-2-yl benzamide derivatives (BZ1-10) were designed and synthesized. The synthesized compounds were characterized by 1H NMR, IR and ESI-MS spectra and also subjected for molecular docking studies with the target DNA gyrase enzyme (PBD ID: 4B6C). The molecular docking results of synthesized derivatives indicated the best docking score of -5.105 and -5.02 for BZ9 and BZ4, respectively. All the synthesized compounds were screened for antitubercular activity against H37RV strain, among all, two compounds exhibited significant activity at 12.5 μg/mL and 25 μg/mL concentrations. Thus, the MIC values are in between range of 12.5 and 6.25 μg/mL concentrations. The teratogenicity assay of synthesized compounds was performed in zebrafish larvae, out of the ten compounds, BZ4, BZ6 and BZ8 compounds were found to safer at 0.5 μM concentration without any abnormalities.

Green approach for highly efficient synthesis of polyhydroquinolines using Fe3 O4@PEO-SO3 H as a novel and recoverable magnetic nanocomposite catalyst

A novel and green heterogeneous nanocomposite, polyethylene oxide sulfonic acid coated on magnetic nanoparticles surface (Fe3 O4 @PEO-SO3 H), was successfully synthesized and completely characterized by Fourier-transforms

Sulfamic Acid-functionalized Nano-titanium dioxide as a Novel and Highly Efficient Heterogeneous Nanocatalyst for One-pot and Solvent-free Synthesis of Hexahydroquinolines

Hexahydroquinolines are synthesized via one-pot, four-component condensation of 1,3-cyclic diketones, aromatic aldehydes, malononitrile, and ammonium acetate in the presence of sulfamic acid-functionalized nano-titanium dioxide as a novel type of heteroge

Choline chloride catalyzed eco-friend and effective one-pot synthesis of 9-arylacridine-1,8-dione and hexahydroquinoline via Hantzsch type reaction

Choline chloride was utilized to efficiently catalyzed Hantzsch type reaction for the synthesis of 9-arylacridine-1,8-dione and hexahydroquinoline derivatives. The optimized catalytic system benefits from facile operation and separation procedures, in goo