129452-87-5

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 139036-59-2 4-N-[2-(tert-butyldiphenylsilyloxymethyl)]benzoyl deoxycytidine 
• 18982-54-2 o-bromobenzyl alcohol 
• 951-77-9 2'-Deoxycytidine 
• 129452-86-4 2-<(tert-butyldiphenylsilyloxy)methyl>benzoyl chloride 
• 132286-88-5 2-(((tert-butyldiphenylsilyl)oxy)methyl)benzoic acid 
• 51432-42-9 4-Amino-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one 
• 398148-63-5 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[2-oxo-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 3992-42-5 2'-deoxycytidine monohydrochloride 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 132286-87-4 (2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane 

Downstream Products

• 140613-57-6 5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite] 
• 129452-90-0 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 139036-69-4 Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 

Relevant academic research and scientific papers

Use of 2-(tert-butyldiphenylsilyloxymethyl) benzoyl as N-protecting group for the synthesis of prooligonucleotides.

A short TCCT Me-SATE prooligonucleotide was successfully synthesized using 2-(tert-butyldiphenyloxymethyl) benzoyl protecting group, after its removal by means of trimethylsilyl chloride and water.

A new protected acyl protecting group for exocyclic amino functions of nucleobases

2-(Tert-butyldiphenylsilyloxymethyl)benzoyl chloride (SiOMB-Cl) reacts with the per-O-trimethylsilylated d-nucleosides C,G and A to give, after removal of the Si(Me)3 groups and 5′-O-protection with 4,4′-dimethoxytrityl chloride (DMT-Cl), the corresponding N-SiOMB-5′-O-DMT derivates, the SiOMB groups of which can easily be removed by fluoride ion. The SiOMB protected nucleosides proved to be suitable building units for the preparation of DNA fragments in solution and on a solid support.