129797-11-1Relevant academic research and scientific papers
Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal β-hexosaminidases
Van Den Berg, Richard J. B. H. N.,Donker-Koopman, Wilma,Van Boom, Jacques H.,Aerts, Hans M. F. G.,Noort, Daan
, p. 891 - 902 (2007/10/03)
As part of a program towards the development of specific inhibitors of human lysosomal β-hexosaminidase for use as chemical chaperones in therapy of GM2 gangliosidosis related diseases, the synthesis of 2-acetamidomethyl derivatives of isofagom
Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
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, (2008/06/13)
The present invention relates to hydroxy alkyl piperidine compounds and pharmaceutical compositions thereof which can be used to treat diabetes.
GLYCOHYDROLASE INHIBITORS, THEIR PREPARATION AND USE THEREOF
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, (2008/06/13)
A compound of the formula, wherein n, m, and p, which may be the same or different, are a number between 0 and 5; q is a number between 0 and 10; R1, R2 R3 R4 and R5, which may be the same or different, are a hydrogen, a hydroxyl, a halogen, a hydrocarbon
Synthesis of Isofagomine, a Novel Glycosidase Inhibitor
Jespersen, Tina M.,Bols, Mikael,Sierks, Michael R.,Skrydstrup, Troels
, p. 13449 - 13460 (2007/10/02)
(3R, 4R, 5R)-3,4-Dihydroxy-5-hydroxymethyl-piperidine (Isofagomine, 1) a potent β-glucosidase inhibitor was synthesised in a 6 step synthesis in an overall yield of 34percent starting from 1,6:2,3-dianhydro-4-O-benzyl-β-D-mannopyranose (7).A hydroxymethyl
Oxirane Ring Opening of Anhydrosugars with Alkynyl- and Alkenylaluminates
Inghardt, Tord,Frejd, Torbjoern
, p. 285 - 291 (2007/10/02)
The oxirane ring opening of 2,3-anhydro-pentopyranosides and 2,3-anhydro-hexopyranosides with organoaluminate reagents is described.By the use of trialkylalkynylaluminates, deoxy-alkynyl sugars are obtained in good yields.Trialkylalkenylaluminates are les
