130159-77-2

Upstream product

• 67-56-1 methanol 
• 32815-00-2 monofumaraldehyde dimethylacetal monomethylester 
• 66646-88-6 methyl 2-(benzylideneamino)acetate 
• 131570-80-4 dimethyl t-3-dimethoxymethyl c-5-phenyl-r-2,c-4-pyrrolidinedicarboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 5837-72-9 methyl (E)-4-oxo-2-butenoate 
• 135075-70-6 (2R,3R,4R,5S)-5-Phenyl-3-((4S,5S)-1,3,4,5-tetraphenyl-imidazolidin-2-yl)-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester 
• 135075-69-3 (2R,3R,4R,5S)-5-Phenyl-3-((4S,5S)-1,3,4,5-tetraphenyl-imidazolidin-2-yl)-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 135075-72-8 (2R,3R,4R,5S)-3-((4R,5R)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester 
• 135075-71-7 (2R,3R,4R,5S)-3-((4R,5R)-1,3-Dimethyl-4,5-diphenyl-imidazolidin-2-yl)-5-phenyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 130179-66-7 (2R,3R,4R,5S)-5-Phenyl-3-((3R,7aS)-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-1-(toluene-4-sulfonyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 131570-79-1 (2R,3R,4R,5S)-3-((2R,4S)-3-Benzyl-4-isopropyl-oxazolidin-2-yl)-5-phenyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 131570-77-9 Methyl (E)-3-<4(S)-3-Benzyl-4-isopropyloxazolidin-2-yl>propenoate 
• 135212-33-8 (2R,3R,4R,5S)-5-Phenyl-3-((4R,5R)-1,3,4,5-tetraphenyl-imidazolidin-2-yl)-pyrrolidine-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester 

Relevant academic research and scientific papers

Diastereoselective Cycloaddition of N-Lithiated Azomethine Ylides to (E)-α,β-Unsaturated Esters Bearing a C2-Symmetric Imidazolidine Chiral Controller

The 1,3-dipolar cycloaddition of N-metalated ylides to chiral (E)-3-(1,3-disubstituted 4,5-diphenylimidazolidin-2-yl)propenoates proceeded highly diastereoselectively.The previously unknown absolute configuration of optically pure 1,2-dianilino-1,2-diphenylethane was determined from the absolute configuration of the cycloadducts.What diastereotopic olefin face of the α,β-unsaturated ester was attacked by the ylide was found to depend dramatically upon the nature of N substituents of the chiral controller as well as upon the bulkiness of the ester moiety of the ylide.

Asymmetric cycloaddition of N-metalated azomethine ylides with the optically active α,β-unsaturated esters derived from α-amino acids

α,β-Unsaturated esters bearing a chiral oxazolidine or perhydropyrrolo[1,2-c]imidazole auxiliary at the β-position have been prepared and applied to the cycloadditions with N-metalated azomethine ylides derived from a-(benzylideneamino) esters. These reac

ASYMMETRIC 1,3-DIPOLAR CYCLOADDITIONS OF AZOMETHINE YLIDES WITH A CHIRAL ELECTRON-DEFICIENT OLEFINIC DIPOLAROPHILE

The first example of efficient asymmetric 1,3-dipolar cycloadditions of azomethine ylides is presented, where reactive N-metalated azomethine ylides and the α,β-unsaturated ester with a chiral perhydropyrroloimidazol-3-yl moiety at the β-position h