130252-75-4

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 341528-94-7 3-iodo-6-methyl-4H-chromen-4-one 
• 89807-39-6 1-(2-hydroxy-5-methylphenyl)-3-(N,N-dimethylamino)propenone 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 89807-39-6 (2E)-3-(dimethylamino)-1-(2-hydroxy-5-methylphenyl)-2-propen-1-one 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 27770-80-5 2-(4-methoxyphenyl)-6-methylchroman-4-one 

Relevant academic research and scientific papers

Arylation of ortho-Hydroxyarylenaminones by Sulfonium Salts and Arenesulfonyl Chlorides: An Access to Isoflavones

Herein we disclose three new methods for the straightforward and efficient synthesis of 3-arylchromones following the arylation of ortho-hydroxyarylenaminones by vast diversities of bench-stable and easy-to-use sulfonium salts and arenesulfonyl chlorides.

Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin

Abstract The synthesis and antimycobacterial activity of formononetin analogues is hereby reported. Formononetin and its analogue 11E showed 88% and 95% growth inhibition, respectively, against the H37Rv strain of Mycobacterium tuberculosis. Pharmacophore modeling studies indicated that the presence of a hydroxyl group in formononetin and its analogues, is crucial for maintaining activity.

Pd-Catalyzed efficient cross-couplings of 3-iodochromones with triarylbismuths as substoichiometric multicoupling organometallic nucleophiles

An efficient cross-coupling of 3-iodochromones with triarylbismuths under catalytic palladium conditions is reported. Triarylbismuths were employed as substoichiometric multicoupling nucleophiles for the synthesis of a variety of substituted isoflavones.

Oxidation of Flavanones using Thallium(III) Salts: A New Route for the Synthesis of Flavones and Isoflavones

When treated with thallium(III) acetate in acetic acid or acetonitrile, flavanones undergo facile dehydrogenation to afford flavones whereas, upon treatment with thallium(III) toluene-p-sulfonate or thallium(III) nitrate in propionitrile or acetonitrile, respectively, they undergo oxidative 2,3-aryl migration to give isoflavones in high yield.

Oxidative 1,2-aryl rearrangement in flavanones using thallium(III) p-tolylsulphonate (TTS): A new useful route to isoflavones

Oxidation of flavanones using thallium(III) p-tolylsulphonate (prepared in situ by the reaction of thallium(III) acetate and p-toluene sulphonic acid) in propionitrile leads to 1,2-aryl shift providing a new useful route to the synthesis of isoflavones.