13031-53-3

Basic information

• Product Name: 1H-Inden-1-one, 3-hydroxy-2-phenyl-
• CAS NO: 13031-53-3
• Molecular Formula: C15H10O2
• Molecular Weight: 222.243
• Mol File: 13031-53-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Inden-1-one, 3-hydroxy-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-1-one, 3-hydroxy-2-phenyl-(13031-53-3)
• EPA Substance Registry System: 1H-Inden-1-one, 3-hydroxy-2-phenyl-(13031-53-3)

Safety Data

• Hazardous Substances Data: 13031-53-3(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 1807-49-4 2-diazo-indan-1,3-dione 
• 71-43-2 benzene 
• 87-41-2 2-benzofuran-1(3H)-one 
• 100-52-7 benzaldehyde 
• 99682-54-9 potassium 3-oxo-1,3-dihydroisobenzofuran-1-carboxylate 

Downstream Products

• 105664-12-8 Z-Glu(OA)-OMe 
• 88621-74-3 Z-Cys(Acm)-OA 
• 583-63-1 ortoquinone 
• 4847-64-7 6-methyl-1,2-benzoquinone 
• 60855-15-4 3-methoxy-[1,2]benzoquinone 
• 32003-14-8 4-benzylphthalazin-1-ol 
• 1313223-17-4 C₂₈H₂₉N₅O 
• 1313223-23-2 C₂₈H₂₆F₃N₅O 
• 1313223-19-6 C₂₇H₂₆ClN₅O 
• 1313223-20-9 C₂₈H₂₆F₃N₅O₂ 
• 1313223-11-8 C₂₇H₂₆FN₅O 
• 1313223-13-0 C₂₉H₂₅F₆N₅O 
• 32003-14-8 4-benzyl-2H-phthalazin-1-one 
• 40848-53-1 1-benzyl-4-chlorophthalazine 

Relevant articles and documents

Synthesis and cytotoxic evaluation of some new phthalazinylpiperazine derivatives

A new series of 1,4-disubstituted phthalazinylpiperazine derivatives 7a-f, 12a-f and 20a-f were designed and synthesized in order to develop potent and selective antitumor agents. The target compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cancer cell lines in vitro. Among them, compounds 7a-f exhibited excellent selectivity for MDA-MB-231 with IC50 values ranging from 0.013 μM to 0.079 μM. The most promising compound, 7e (IC50 = 2.19 μM, 2.19 μM, 0.013 μM), was 9.3, 10, and 4.9 × 103 times more active than vatalanib (IC50 = 20.27 μM, 21.96 μM, 63.90 μM), respectively. A new series of 1,4-disubstituted phthalazinylpiperazine derivatives 7a-f, 12a-f and 20a-f were designed and synthesized, and their cytotoxic activities against A549, HT-29 and MDA-MB-231 cancer cell lines in vitro were compared to that of vatalanib.

Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives

A series of 1,4-substituted phthalazine derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, HT-29 and MDA-MB-231 cell lines in vitro. Among them, compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1nmol/L to 0.92μmol/L. A preliminary SAR study of these derivatives was performed.

The Chemistry of Phthalide-3-carboxylic Acid. II. Decarboxylation of Salts in the Presence of Aldehydes

Salts of phthalide-3-carboxylic acid decarboxylate in the presence of aromatic aldehydes to give mixtures of the 3-(arylhydroxymethyl)phthalide (2) and the 2-aryl-3-hydroxyindenone (3).The former may be obtained exclusively in the presence of the weak proton donor, triethyl(2-phenylethyl)ammonium chloride, and the latter in the presence of crown ethers or after longer reaction times.A study of the effect of different cations allows a mechanism to be deduced.