130422-86-5

Basic information

• Product Name: Phenol, 4-methoxy-2,3,5-trimethyl-
• CAS NO: 130422-86-5
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Mol File: 130422-86-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenol, 4-methoxy-2,3,5-trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-methoxy-2,3,5-trimethyl-(130422-86-5)
• EPA Substance Registry System: Phenol, 4-methoxy-2,3,5-trimethyl-(130422-86-5)

Safety Data

• Hazardous Substances Data: 130422-86-5(Hazardous Substances Data)

Upstream product

• 1629281-17-9 C₁₅H₂₂O₃ 
• 112109-69-0 4-hydroxy-2,3,5-trimethylphenyl pivalate 
• 607351-70-2 4-tert-butyldimethylsilyloxy-2,3,6-trimethylphenol 
• 700-13-0 Trimethylhydroquinone 
• 607351-71-3 4-tert-butyldimethylsilyloxy-1-methoxy-2,3,6-trimethylbenzene 
• 74-88-4 methyl iodide 
• 64-19-7 acetic acid 
• 79-21-0 peracetic acid 

Downstream Products

• 186537-56-4 (2RS,4R,8R)-α-tocopherol 
• 1629168-03-1 1-(2-hydroxy-5-methoxy-3,4,6-trimethylphenyl)ethanone 
• 1629168-06-4 C₂₉H₄₈O₄ 
• 32466-45-8 (2R,4'R,8'R)-α-tocopheryl methyl ether 
• 1266327-72-3 C₃₀H₅₂O₂ 
• 1215112-51-8 (2R,6R,10R)-2-(4-methoxy-2,3,5-trimethylphenoxy)-2,6,10,14-tetramethylpentadecanoic acid methyl ester 
• 607351-64-4 4-methoxy-3,4,6-trimethylbenzene-1,2-diol 
• 607351-63-3 2-hydroxy-5-methoxy-3,4,6-trimethylbenzaldehyde 

Relevant articles and documents

Total synthesis of (2RS)-α-tocopherol through Ni-catalyzed 1,4-addition to a chromenone intermediate

A novel strategy for the total synthesis of α-tocopherol ("vitamin E") was elaborated on the basis of the conjugate addition of AlMe3 (as a methyl anion equivalent) to a 2-substituted chromenone. Starting from trimethylhydroquinone and (R,R)-he

REGIOSELECTIVE SYNTHESIS OF 2,3,5-TRIMETHYL-p-BENZOQUINONE MONOACETAL AND ITS TRANSFORMATIONS

The addition of ethylene glycol to 2,3,5-trimethylbenzoquinone takes place regioselectively at the less screened carbonyl at position 1. 2,3,5-Trimethyl-p-benzoquinone ethylene 1-acetal is formed.The ethylene acetal protection is removed by acid hydrolysis.The use of ethylene acetal protection opened up a path to quinols containing aliphatic radicals at the carbonyl carbon.

REACTION OF 1,2,4-TRIMETHYLBENZENE WITH PERACETIC ACID

The oxidation of 1,2,4-trimethylbenzene with peracetic acid leads to the formation of trimethylphenols and hydroquinones, which undergo transformations to the corresponding benzoquinones and products from oxidative cleavage of the ring.The controlling stage of the process is the electrophilic hydroxylation of 1,2,4-trimethylbenzene.