130422-86-5

Upstream product

• 79-21-0 peracetic acid 
• 700-13-0 Trimethylhydroquinone 
• 64-19-7 acetic acid 
• 74-88-4 methyl iodide 
• 1629281-17-9 C₁₅H₂₂O₃ 
• 112109-69-0 4-hydroxy-2,3,5-trimethylphenyl pivalate 
• 607351-70-2 4-tert-butyldimethylsilyloxy-2,3,6-trimethylphenol 
• 607351-71-3 4-tert-butyldimethylsilyloxy-1-methoxy-2,3,6-trimethylbenzene 

Downstream Products

• 607351-63-3 2-hydroxy-5-methoxy-3,4,6-trimethylbenzaldehyde 
• 1266327-72-3 C₃₀H₅₂O₂ 
• 186537-56-4 (2RS,4R,8R)-α-tocopherol 
• 1629168-03-1 1-(2-hydroxy-5-methoxy-3,4,6-trimethylphenyl)ethanone 
• 1629168-06-4 C₂₉H₄₈O₄ 
• 32466-45-8 (2R,4'R,8'R)-α-tocopheryl methyl ether 
• 1215112-51-8 (2R,6R,10R)-2-(4-methoxy-2,3,5-trimethylphenoxy)-2,6,10,14-tetramethylpentadecanoic acid methyl ester 
• 607351-64-4 4-methoxy-3,4,6-trimethylbenzene-1,2-diol 

Relevant academic research and scientific papers

Total synthesis of (2RS)-α-tocopherol through Ni-catalyzed 1,4-addition to a chromenone intermediate

A novel strategy for the total synthesis of α-tocopherol ("vitamin E") was elaborated on the basis of the conjugate addition of AlMe3 (as a methyl anion equivalent) to a 2-substituted chromenone. Starting from trimethylhydroquinone and (R,R)-he

Development of novel antioxidants: Design, synthesis, and reactivity

We are attempting to develop novel synthetic antioxidants aimed at retarding the effects of free-radical induced cell damage. In this paper we discuss the design strategy and report the synthesis of seven novel antioxidants, including six catechols and a

REGIOSELECTIVE SYNTHESIS OF 2,3,5-TRIMETHYL-p-BENZOQUINONE MONOACETAL AND ITS TRANSFORMATIONS

The addition of ethylene glycol to 2,3,5-trimethylbenzoquinone takes place regioselectively at the less screened carbonyl at position 1. 2,3,5-Trimethyl-p-benzoquinone ethylene 1-acetal is formed.The ethylene acetal protection is removed by acid hydrolysis.The use of ethylene acetal protection opened up a path to quinols containing aliphatic radicals at the carbonyl carbon.

REACTION OF 1,2,4-TRIMETHYLBENZENE WITH PERACETIC ACID

The oxidation of 1,2,4-trimethylbenzene with peracetic acid leads to the formation of trimethylphenols and hydroquinones, which undergo transformations to the corresponding benzoquinones and products from oxidative cleavage of the ring.The controlling stage of the process is the electrophilic hydroxylation of 1,2,4-trimethylbenzene.