13053-82-2Relevant academic research and scientific papers
A novel and efficient amidation of 2-aminothiazole
Choi, Minho,Won, Sun-Woo,Jo, Hyeju,Viji, Mayavan,Seo, Seung-Yong,Lee, Yeon-Ju,Lee, Hyi-Seung,Lee, Heesoon,Hong, Jin Tae,Kwak, Young-Shin,Jung, Jae-Kyung
, p. 6582 - 6584 (2014)
A facile and efficient method has been developed for the synthesis of novel thiazolyl carboxamide derivatives by direct reaction of the corresponding esters and 2-aminothiazole. Treatment of 2-aminothiozole with various carboxylic esters in the presence of t-butylmagnesium chloride provides the biologically significant thiazolyl carboxamide derivatives in good to excellent yields.
Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines
Cheruku, Srinivas,Sajith, Ayyiliath M.,Narayana, Yatheesh,Shetty, Poornima,Nagarakere, Sandhya C.,Sagar, Kunigal S,Manikyanally, Kumara N.,Rangappa, Kanchugarkoppal Subbegowda,Mantelingu, Kempegowda
, p. 5530 - 5537 (2021/05/07)
Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.
Solar and visible-light active nano Ni/g-C3N4photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions
Hosseini-Sarvari, Mona,Akrami, Zahra
, p. 956 - 969 (2021/02/26)
In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands. Similar reactions are carried out at high temperatures, in the presence of appropriate ligands, stoichiometric amounts of bases, and gaseous carbon monoxide, which endanger the health of organic chemists. We present a novel method that does not utilize ligands, bases, gaseous CO, and special conditions. This procedure is a redox reaction carried out by new economic nano Ni/g-C3N4at room temperature and under visible light. Mo(CO)6was used toin situgenerate CO, to resolve the problems caused by the use of CO gas. This protocol has the ability to be used on a gram scale by using a continuous flow reactor.
Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents
Modri?, Marina,Bo?i?evi?, Marin,Faraho, Ivan,Bosnar, Martina,?kori?, Irena
, (2021/05/06)
Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFα and IL-8 release with IC50 values in μM range without cytotoxic activity.
Nickel/briphos-catalyzed transamidation of unactivated tertiary amides
Kim, Hyunwoo,Lee, Sunwoo,Shin, Taeil,Yang, Dahyeon
supporting information, p. 6053 - 6057 (2020/10/27)
The transamidation of tertiary amides was achieved via nickel catalysis in combination with briphos ligands. N-Methyl-N-phenylbenzamide derivatives reacted with primary amines in the presence of NiCl2/briphos L4 to provide the transamidated products in moderate to good yields. Primary aromatic amines delivered higher product yields than aliphatic amines.
N-(thiazol-2-yl)benzamide derivatives as a new series of supramolecular gelators: Role of methyl functionality and S?O interaction
Yadav, Priyanka,Ballabh, Amar
, (2019/11/13)
A new series of N-(thiazol-2-yl) benzamide derivatives were synthesized, characterized and investigated for their gelation behavior with the aim to elucidate the role of methyl functionality and multiple non-covalent interactions on gelation/non-gelation
Potassium tert-Butoxide Prompted Highly Efficient Transamidation and Its Coordination Radical Mechanism
Tan, Zhiyong,Li, Zhenhua,Ma, Yao,Qin, Jinjing,Yu, Chuanming
supporting information, p. 4538 - 4545 (2019/07/18)
A simple and highly efficient protocol was developed for the transamidation of N,N-disubstituted amides with primary amines in the presence of tBuOK, affording desired products in good to excellent yields. This reaction proceeded under nitrogen atmosphere and featured extensive substrate tolerance. Experimental investigation suggested that a coordination radical process enhanced this transformation.
Method for preparing derivatives of benzamide under microwave condition in aqueous phase
-
Paragraph 0019; 0066, (2019/03/28)
The invention discloses a method for preparing derivatives of benzamide under a microwave condition in an aqueous phase. A coupling reaction is carried out between substituted benzoic acid and amine under the microwave condition in the aqueous phase. The method for preparing the derivatives of benzamide is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applicable to a large number of functional groups, is high in yield, produces fewer by-products, and further is easy to operate, safe, low in cost and environmentally friendly. A formula is shown in the description.
Electrochemical: N-acylation synthesis of amides under aqueous conditions
Ke, Fang,Xu, Yiwen,Zhu, Suning,Lin, Xiaoyan,Lin, Chen,Zhou, Sunying,Su, Huimin
supporting information, p. 4329 - 4333 (2019/08/21)
An electrochemical N-acylation of carboxylic acids with amines was reported. The sustainable TBAB electrocatalysis proceeded with excellent chemoselectivity and positional selectivity, and with ample scope, allowing electrochemical N-acylation under mild reaction conditions at room temperature in water. Moreover, the synthetic utility of the current method is demonstrated by the synthesis of melatonin.
Aminothiazoles and aminothiadiazoles as nucleophiles in aminocarbonylation of iodobenzene derivatives
Gergely, Máté,Kollár, László
, p. 2030 - 2040 (2018/03/21)
Various 2-, 3- and 4-substituted iodobenzenes were aminocarbonylated using aminothiazole and aminothiadiazole derivatives in palladium-catalysed reaction. The reaction is chemospecific toward the corresponding carboxamides. Consequently, the application o
