24442-57-7

Basic information

• Product Name: 1,2-Dibromoethyl acetate
• Synonyms: 1,2-DIBROMOETHYLACETATE,=98.0%;1,2-Dibromoethyl acetate;Acetic acid 1,2-dibromoethyl ester
• CAS NO: 24442-57-7
• Molecular Formula: C₄H₆Br₂O₂
• Molecular Weight: 245.9
• EINECS: 246-249-0
• Mol File: 24442-57-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 231.5 °C at 760 mmHg
• Flash Point: 93.8 °C
• Appearance: /
• Density: 1.97 g/cm³
• Vapor Pressure: 0.0621mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 1,2-Dibromoethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dibromoethyl acetate(24442-57-7)
• EPA Substance Registry System: 1,2-Dibromoethyl acetate(24442-57-7)

Safety Data

• Hazardous Substances Data: 24442-57-7(Hazardous Substances Data)

Usage

General Description

1,2-Dibromoethyl acetate is a chemical compound with the molecular formula C4H6Br2O2. It is an organic compound that contains two bromine atoms and an acetate group. This colorless liquid is used primarily in the production of pharmaceuticals and as an intermediate in organic synthesis. It is a versatile building block that is used in the manufacture of a variety of chemicals, including pesticides, herbicides, and other agricultural chemicals. Its properties make it a valuable component in the production of pharmaceuticals and other medicinal products. Additionally, it is used in research laboratories for various chemical reactions and processes. However, 1,2-Dibromoethyl acetate is toxic and should be handled and disposed of with caution.

InChI:InChI=1/C4H6Br2O2/c1-3(7)8-4(6)2-5/h4H,2H2,1H3

Upstream product

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Downstream Products

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• 1127238-39-4 2-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methylethyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
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Relevant articles and documents

Crystal structure, characterization, Hirshfeld surface analysis and DFT studies of two [propane 3-bromo-1-(triphenyl phosphonium)] cations containing bromide (I) and tribromide (II) anions: The anion (II) as a new brominating agent for unsaturated compounds

In this study, propane 3-bromo-1- (triphenyl phosphonium) bromide, I, and propane 3-bromo-1- (triphenyl phosphonium) tribromide, II, (II as a new brominating agent) were synthesized and characterized by 1H NMR, 13C NMR, 31P NMR, FT-IR, spectroscopy, Thermogravimetric Analysis, Differential thermal analysis, Differential scanning calorimetry and single crystal X-ray analysis. Density functional theory calculations (energy, structural optimization and frequencies, Natural Bond Orbital, absorption energy and binding energy) were performed by using B3LYP/6-311 G++ (d, p) level of theory. Hirshfeld surface analysis and fingerprint plots were utilized to investigate the role of bromide and tribromide anions on the crystal packing structures of title compounds. The results revealed that the change of accompanying anionic moiety can affect the directional interactions of C-H?Br hydrogen bonds between anionic and cationic units in which the H?Br with a proportion of 53.8% and 40.9% have the major contribution in the stabilization of crystal structures of I and II, respectively. Furthermore, the thermal stability of new brominating agent II with tribromide anion was compared with compound I with bromide anion. Nontoxicity, short reaction time, thermal stability, simple working up and high yield are some of the advantages of these salts.

PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR?, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors

Endothelial lipase (EL) activity has been implicated in HDL catabolism, vascular inflammation, and atherogenesis, and inhibitors are therefore expected to be useful for the treatment of cardiovascular disease. Sulfonylfuran urea 1 was identified in a high-throughput screening campaign as a potent and non-selective EL inhibitor. A lead optimization effort was undertaken to improve potency and selectivity, and modifications leading to improved LPL selectivity were identified. Radiolabeling studies were undertaken to establish the mechanism of action for these inhibitors, which were ultimately demonstrated to be irreversible inhibitors.