130539-14-9Relevant academic research and scientific papers
1,3-Dideoxynojirimycin-3-yl glycosides of β-(1→3)- and β-(1→6)-linked gluco-oligosaccharides
Blattner, Regine,Furneaux, Richard H.,Pakulski, Zbigniew
, p. 2115 - 2125 (2007/10/03)
Standard chemical methods involving the use of O-acetylated glycosyl trichloroacetimidates as glycosylating agents were used to prepare the five 1,3-dideoxynojirimycin-3-yl β-(1→3)-linked oligo-glucosides (1-5) and also the β-(1→6)-bonded glucobiose (gent
Design and synthesis of a heparanase inhibitor with pseudodisaccharide structure
Takahashi, Shunya,Kuzuhara, Hiroyoshi,Nakajima, Motowo
, p. 6915 - 6926 (2007/10/03)
Aza-analogue of the basic disaccharide unit of heparane sulfate was designed as a potent inhibitor against heparanase produced by solid tumors cell, and synthesized via a coupling reaction of phenyl 2-azide-1-thio-D-glucopyranoside derivatives with a partially protected 1-deoxynojirimycin derived from D-glucose. The azapseudodisaccharide inhibited tumor cell heparanase with IC50 value of 58-63 μM.
