130600-30-5

Upstream product

• 127-19-5 N,N-dimethyl acetamide 
• 165180-44-9 N-(4-bromo-2-fluorophenyl)pivalamide 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 367-24-8 4-bromo-2-fluoroaniline 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 152835-71-7 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one 
• 165179-82-8 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methyl-5-pivaloylamino-4H-1-benzopyran-4-one 
• 165179-92-0 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methylthio-5-pivaloylamino-4H-1-benzopyran-4-one 
• 165179-95-3 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-hydroxy-5-pivaloylamino-4H-1-benzopyran-4-one 
• 165180-38-1 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-hydroxymethyl-5-pivaloylamino-4H-1-benzopyran-4-one 
• 1026753-19-4 N-{2-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-6,8-dimethyl-4-oxo-4H-chromen-5-yl}-2,2-dimethyl-propionamide 
• 189691-39-2 2-[3-fluoro-4-(pivaloylamino)phenyl]-8-methyl-5-(pivaloylamino)-4H-1-benzopyran-4-one 
• 152169-56-7 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one 
• 165179-90-8 7-bromo-6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one 
• 165179-35-1 5-Amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Synthesis of an ethyl 6-amino-3,5-difluorosalicylate derivative by sequential regioselective directed ortho- metalation; a practical synthesis of 4',5-Diamino-3',6,8-trifluoroflavone, a potent antitumor agent

The multigram scale synthesis of 4',5-diamino-3'6,8-trifluoroflavone, a potent antitumor agent, is described in which regioselective introduction of a carbonyl group into the ortho-position to the amide group of 2-[2,4-difluoro-5-(pivaloylamino)phenyoxy]tetrahydropyran is achieved by using sequential direct ortho-metalations as the key step.

Design and synthesis of potent antitumor 5,4'-diaminoflavone derivatives based on metabolic considerations

Recently, we reported that 5,4'-diaminoflavone (1) exhibits potent and specific growth-inhibitory activity against the estrogen receptor (ER)- positive human breast cancer cell line MCF-7. However, when compound 1 was incubated with S-9 mix, its metabolit

5-AMINOFLAVONE DERIVATIVES

The present invention relates to a 5-aminoflavone derivative represented by the formula (I): wherein X represents substituted lower alkyl, unsubstituted or substituted lower alkoxy, or NR1R2(wherein R1and R2are

5-aminoflavone derivatives

5-Aminoflavone derivatives represented by the formula (I): STR1 wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substi

5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent

5-Aminoflavone derivatives represented by the formula (I): wherein R1 and R2 are the same or different and represent hydrogen or substituted or unsubstituted lower alkyl, X represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl,