130747-67-0

Upstream product

• 124-41-4 sodium methylate 
• 16616-43-6 1-(4-methoxy-phenyl)-3-phenyl-propynone 
• 109-77-3 malononitrile 
• 67-56-1 methanol 
• 100-52-7 benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1240155-59-2 methyl 6-amino-5-cyano-3-(4-methoxybenzoyl)-4-phenyl-4H-pyran-2-carboxylate 
• 959-23-9 4'-methoxychalcone 

Relevant academic research and scientific papers

Microwave-Assisted, One-Pot Multicomponent Synthesis of Some New Cyanopyridines

An efficient and facile synthesis of cyanopyridines via a one-pot four-component reaction of aromatic aldehydes, acetophenones, malononitrile, or 2-aminoprop-1-ene-1,1,3-tricarbonitrile in presence of sodium alkoxide or ammonium acetate under both microwave and thermal reaction conditions was introduced.

Synthesis and reactivity of methyl 3-acyl-6-amino-4-aryl-5-cyano-4h-pyran- 2-carboxylates

By treating arylidenemalononitriles with methyl 2,4-dioxobutanoates, derivatives of 4H-pyrans - methyl 3-acyl-6-amino-4-aryl-5-cyano-4H-pyran-2- carboxylates - are obtained, which are novel, promising structural components for the synthesis of carbo- and

Synthesis of polysubstituted pyridines under combined microwave and ultrasound irradiation: K2CO3-promoted tandem addition/cyclization/hydrogen shift process

A convenient and efficient K2CO3-promoted tandem reaction of chalcone, malononitrile, and methanol for the synthesis of highly functionalized pyridines has been developed. This multi-component reaction employing the weak nucleophilic agent methanol proceeded smoothly under combined microwave and ultrasound irradiation (CMUI). The reaction mechanism was proposed to consist of a Michael addition, a methoxylation of CN bond, a cyclization to a 1,4-dihydropyridine and an intermolecular hydrogen shift between 1,4-dihydropyridine and initial chalcone.

Reactions of Malononitrile with Acetylenic Esters and Ketones

The addition of malononitrile to acetylenic esters and acetylenic ketones catalysed by sodium alkoxides leads to the formation of 3- and 5-cyano-2-pyridones, 2-cyano- and 2,6-dicyano-aniline derivatives, and other products.