130780-10-8Relevant academic research and scientific papers
Nafion-catalyzed microwave-assisted Ritter reaction: an atom-economic solvent-free synthesis of amides
Polshettiwar, Vivek,Varma, Rajender S.
, p. 2661 - 2664 (2008)
An atom-economic solvent-free synthesis of amides by the Ritter reaction of alcohols and nitriles under microwave irradiation is reported. This green protocol is catalyzed by solid-supported NafionNR50 with improved efficiency and reduced waste production.
Visible light-promoted self-coupling of N-chloramines at room temperature: A metal-free access to substituted amides
Chaubey, Narendra R.
supporting information, p. 3546 - 3552 (2019/11/14)
An efficient protocol to synthesize substituted amides via self-coupling of N-chlorobenzylamines has been developed under visible light-promoted mild condition. Both the electron-deficient and electron-rich benzylamines undergo self-coupling very readily to produce the amide linkage under given reaction conditions.
Design and synthesis of arylamidine derivatives as serotonin/norepinephrine dual reuptake inhibitors
Wen, Hui,Qin, Wen,Yang, Guangzhong,Guo, Yanshen
, (2019/02/03)
To improve the in vivo antidepressant activity of previously reported serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors, three series of arylamidine derivatives were designed and synthesized. The in vitro 5-HT and NE reuptake inhibitory activities of these compounds were evaluated, and compound II-5 was identified as the most potent 5-HT (IC50 = 620 nM) and NE (IC50 = 10 nM) dual reuptake inhibitor. Compound II-5 exhibited potent antidepressant activity in the rat tail suspension test and showed an acceptable safety profile in a preliminary acute toxicity test in mice. Our results show that these arylamidine derivatives exhibit potent 5-HT/NE dual reuptake inhibition and should be explored further as antidepressant drug candidates.
Synthesis of bis(2,4-diarylimidazol-5-yl) diselenides from N-benzylbenzimidoyl isoselenocyanates
Atanassov, Plamen K.,Zhou, Yuehui,Linden, Anthony,Heimgartner, Heinz
, p. 1102 - 1117 (2007/10/03)
The reaction of N-benzylbenzamides 6 with SOCl2 under reflux gave the corresponding N-benzylbenzimidoyl chlorides 7. Further treatment with KSeCN in dry acetone yielded imidoyl isoselenocyanates 3 (Scheme 2). These compounds, obtained in satisfying yields, proved to be stable enough to be purified and analyzed. Reaction of 3 with morpholine in dry acetone led to the corresponding selenourea derivatives 8. On treatment with Et3N, the 4-nitrobenzyl derivatives of type 3 were transformed into bis(2,4-diarylimidazol-5-yl) diselenides 9 (Scheme 3). This transformation takes place only when the benzyl residue bears an NO2 group and the phenyl group is not substituted with a strong electron-donating group. A reaction mechanism for the formation of 9 is proposed in Scheme 4. The key structures have been established by X-ray crystallography.
