13084-29-2

Usage

Chemical structure

Contains a thiazole ring and a chlorine-substituted phenyl group

Kinase activity

Potent and selective inhibitor of the epidermal growth factor receptor (EGFR)

Therapeutic potential

Being investigated for its potential effects in the treatment of various cancers, particularly non-small cell lung cancer

Preclinical and clinical results

Has shown promising results in inhibiting tumor growth

Targeted therapy

Being studied for its potential as a targeted therapy in cancer treatment

Further research

Its chemical structure and mechanism of action make it a promising candidate for further research and development in the field of oncology.

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 60-23-1 Cysteamine 
• 4640-66-8 p-chlorobenzoylacetonitrile 
• 7400-54-6 4-chloro-N-(2-hydroxyethyl)-benzamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 3848-36-0 4-chlorobenzaldoxime 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 104-88-1 4-chlorobenzaldehyde 
• 153784-01-1 [(4-Chloro-phenyl)-oxo-ethanesulfonyl]-acetic acid methyl ester 
• 51847-02-0 4-chloro-N-(2-chloroethyl)benzamide 
• 4231-70-3 p-chlorobenzoyl-1H-1,2,3-benzotriazole 
• 36926-21-3 4-chloro-N-(2-hydroxyethyl)benzothioamide 
• 13094-95-6 1-(4-chloro-thiobenzoyl)-aziridine 

Downstream Products

• 96159-99-8 2-(4-Chloro-phenyl)-3-methyl-4,5-dihydro-thiazol-3-ium; iodide 
• 27149-26-4 2-(4-chlorophenyl)thiazole 

Relevant academic research and scientific papers

Tribromomelamine: A novel and efficient catalyst for the synthesis 2-arylthiazolines under solvent-free conditions

A novel procedure for the synthesis of 2-arylthiazolines through one-pot condensation of of nitriles with 2-aminoethanethiol in the presence of tribromomelamine as catalyst under solvent-free conditions is described.

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.

Cu(II) immobilized on Fe3O4@Agarose nanomagnetic catalyst functionalized with ethanolamine phosphate–salicylaldehyde schiff base: A magnetically reusable nanocatalyst for preparation of 2-substituted imidazolines, oxazolines, and thiazolines

Herein we synthesized Cu(II) immobilized on Fe 3 O 4 @Agarose functionalized with ethanolamine phosphate–salicylaldehyde Schiff base (Fe 3 O 4 @Agarose/SAEPH 2 /Cu(II)) as a new and cost-effective nanomagnetic catalyst. The nanomagnetic catalyst was characterized by FT- IR, XRD, VSM, SEM- EDX, TEM, TGA, and ICP techniques and it was found that the particles were about 9–25 nm in size and spherical with entrapment of the Fe 3 O 4 particles in the hollow pore structure of the agarose. The prepared nanomagnetic catalyst showed excellent activity for preparation of 2-substituted imidazolines, oxazolines, and thiazolines. The catalyst is easy to prepare and exhibits higher catalytic activity than some commercially available copper sources. More importantly, this nanomagnetic catalyst can be easily recovered by using a permanent magnet and reused for at least seven cycles without significant deactivation.

A straightforward metal-free synthesis of 2-substituted thiazolines in air

A base-catalysed procedure for the synthesis of 2-substituted thiazolines from nitriles and cysteamine hydrochloride under solvent-free conditions is presented. This straightforward approach allows high conversion for a broad range of nitriles and an easy

A single-reagent-driven multistep one-pot preparation of thiazolines and 1,3-thiazines from aldoximes, nitriles, and carboxylic acids

N-(ω-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from ald-oximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

Solvent-free tandem synthesis of 2-thiazolines and 2-oxazolines catalyzed by a copper catalyst

Tandem reactions of nitriles with 2-aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate (Cu II2L4, L = methacrylate) were employed to prepare 2-thiazolines and 2-ox

Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition

Trichloroisocyanuric acid, as a commercially available and inexpensive catalyst, was used in a new, facile and efficient procedure for the synthesis of 2-oxazolines, 2-imidazolines and 2-thiazolines through the reaction of nitriles with 2-aminoethanol, ethylenediamine or 2-aminoethanethiol under solvent-free conditions.

One-pot synthesis of 2-arylthiazolines with 1-butyl-3-methylimidazolium tribromide as a catalytic reagent

A simple, inexpensive, and efficient one-pot synthesis of 2-arylthiazoline derivatives under solvent-free conditions using a catalytic amount of 1-butyl-3-methylimidazolium tribromide with excellent product yields is reported. This methodology provides ea

1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for the synthesis of 2-arylthiazolines and 2-arylimidazolines

A simple, facile, and efficient procedure for the synthesis of 2-arylthizolines and 2-arylimidazolines has been developed by the simple condensation of nitriles with 2-aminoethanethiol or ethylenediamine catalyzed by 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions. Selective preparation of bisthiozolines and monoimidazolines from dinitriles and also selective conversion of arylnitriles to their corresponding 2-arylthiazolines or imidazolines in the presence of alkylnitriles can be considered as considerable advantages of this method.