1308866-07-0Relevant articles and documents
Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions
Bacchi, Alessia,Carfagna, Carla,Costa, Mirco,Della Ca', Nicola,Gabriele, Bartolo,Mancuso, Raffaella,Mazzeo, Paolo P.,Pancrazzi, Francesco,Sarti, Nicolò,Stirling, András
supporting information, p. 1569 - 1574 (2020/03/13)
In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C-O, two C-C, five C-N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies.
One-pot strategy of copper-catalyzed synthesis of 1,2-disubstituted benzimidazoles
Xie, Caixia,Han, Xushuang,Gong, Jian,Li, Danyang,Ma, Chen
supporting information, p. 5811 - 5819 (2017/07/22)
A simple, one-pot and copper-catalyzed coupling reaction for the construction of 1,2-disubstituted benzimidazole derivatives is described. A low-cost copper salt and a weak base K3PO4 were utilized in this reaction. A variety of 1,2-disubstituted benzimidazoles were obtained in moderate to excellent yields.
Potassium tert-butoxide promoted intramolecular arylation via a radical pathway
Roman, Daniela Sustac,Takahashi, Yoko,Charette, Andre B.
, p. 3242 - 3245 (2011/08/02)
Potassium tert-butoxide mediated intramolecular cyclization of aryl ethers, amines, and amides was efficiently performed under microwave irradiation to provide the corresponding products in high regioisomeric ratios. The reaction proceeds via single-electron transfer to initiate the formation of an aryl radical, followed by a kinetically favored 5-exo-trig and subsequent ring expansion.
