1309604-04-3

Upstream product

• 1309603-90-4 (1,3-dithian-2-yl)(3,4,5-trimethoxyphenyl)methanone 
• 352-13-6 4-flourophenylmagnesium bromide 
• 1379793-90-4 C₉H₁₁ClMgO₃ 
• 359784-71-7 C₁₁H₁₆N₂O₃ 
• 93480-06-9 (1-(4-fluorophenyl)ethylidene)hydrazine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 1309604-00-9 2-(4-fluorophenyl)-2-(3,4,5-trimethoxyphenyl)ethanol 
• 1309603-94-8 2-((4-fluorophenyl)(3,4,5-trimethoxyphenyl)methyl)-1,3-dithiane 

Relevant academic research and scientific papers

α,α-Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1-Diarylethenes and α,α-Diaryl Acetaldehydes

Towards assembling of diarylmethine unit present in biologically important molecules, we have developed a new Weinreb Amide (WA) based building block derived from glycolic acid. The WA functionality present in this building block permits the sequential addition of various arylmagnesium bromide reagents in a controlled manner that enables assembly of a diarylmethine unit. The developed synthetic route provides easy access to important diarylethenes and α,α-diarylethylene glycols. The synthesized α,α-diarylethylene glycols provide access to synthetically important symmetrical and unsymmetrical α,α-diaryl acetaldehydes as valuable intermediates.

Synthesis of 1,1-diarylethylenes via efficient iron/copper Co-catalyzed coupling of 1-arylvinyl halides with Grignard reagents

An efficient access to 1,1-diarylethylenes of biological interest by coupling functionalized aryl Grignard reagents and 1-arylvinyl halides in the presence of FeCl3/CuTC is described. This bimetallic system proved to be superior to the use of Fe or Cu catalyst alone. The synthetic utility of this protocol is illustrated in the field of steroid chemistry.

Weinreb amide based building blocks for convenient access to 1,1-diarylethenes and isocombretastatin analogues

A successful strategy based on the synthetic equivalent containing Weinreb amide functionality for the convenient access to 1,1-diarylethenes in general and for the isocombretastatin analogues in particular has been developed from the commercially available glyoxalic acid. The convenience with which the structural variations can be made in assembling the aryl residues shows generality associated with the developed strategy. The intermediates also provide access to 1,2,2-triarylethanones, represented by the synthesis of advanced intermediate of tamoxifen.