1310709-07-9

Basic information

• Product Name: 2-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-indole
• Synonyms: 2-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-indole
• CAS NO: 1310709-07-9
• Molecular Weight: 300.36
• Mol File: 1310709-07-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-indole(1310709-07-9)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-indole(1310709-07-9)

Safety Data

• Hazardous Substances Data: 1310709-07-9(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 120-72-9 indole 
• 1008-89-5 2-phenylpyridine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 3419-91-8 N-(2-pyridyl)indole 
• 221044-05-9 N-(2-pyrimidyl)indole 
• 623-12-1 4-chloromethoxybenzene 
• 7305-10-4 4-methoxyphenyl dimethylcarbamate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 107915-69-5 N-(4-methoxybenzoyl) saccharin 
• 100-07-2 4-methoxy-benzoyl chloride 
• 696-62-8 para-iodoanisole 
• 6631-37-4 2-(phenylamino)pyridine 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis of 2-substituted indoles by iridium (III)-catalyzed C–]H functionalization of N-phenylpyridin-2-amines

A highly regioselective synthesis of 2-substituted indoles was realized through Ir(III)-catalyzed C–]H functionalization of N-phenylpyridin-2-amines followed by the reaction with sulfoxonium ylides and intramolecular cyclization under mild conditions. The reaction completed with broad range of substrate scopes and gave various 2-substituted indoles in up to 98% yields.

Iridium(III)-Catalyzed Tandem Annulation of Pyridine-Substituted Anilines and α-Cl Ketones for Obtaining 2-Arylindoles

A facile and expeditious protocol for the synthesis of 2-arylindole compounds from readily available N-(2-pyridyl)anilines and commercially available α-Cl ketones through iridium-catalyzed C-H activation and cyclization is reported here. As a complementary approach to the conventional strategies for indole synthesis, the transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds with good to excellent yields under mild conditions, providing a straightforward method to obtain structurally diverse and valuable indole scaffolds. Furthermore, the reaction could be easily scaled up to gram scale.

Ruthenium-catalyzed synthesis of indole derivatives from: N -aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides

Indole is a ubiquitous structural motif with important applications in many areas of chemistry. Given this, a simple and efficient Ru(ii)-catalyzed synthesis of indole via intermolecular annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed. This protocol provides easy access to a wide variety of useful indoles in the presence of a commercially available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks.