131146-87-7Relevant academic research and scientific papers
Synthesis and in vitro anticancer activity evaluation of novel bioreversible phosphate inositol derivatives
Chen, Wenbin,Deng, Zhaohui,Chen, Kuangyu,Dou, Daolei,Song, Fanbo,Li, Luyuan,Xi, Zhen
supporting information, p. 172 - 181 (2015/03/05)
The chemistry and biology of phosphorylated inositols have become intense areas of research during the last two decades due to their involvement in various cellular signaling processes. However, the metabolic instability by phosphatases or kinases and poo
Resolution of orthogonally protected myo-inositols with Novozym 435 providing an enantioconvergent pathway to Ac2PIM1
Lee, Alastair M. M.,Painter, Gavin F.,Compton, Benjamin J.,Larsen, David S.
, p. 10916 - 10931 (2015/01/09)
Orthogonally protected chiral myo-inositol derivatives are important intermediates for higher order myo-inositol-containing compounds. Here, the use of the immobilized enzyme Novozym 435 to efficiently catalyze the acetylation of the 5R configured enantio
Synthesis of 3-Position-Modified Analogues of myo-Inositol 1,4,5-Trisphosphate, Tools for Investigation of the Polyphosphoinositide Pathway of Cellular Signaling
Liu, Changsheng,Potter, Barry V. L.
, p. 8335 - 8338 (2007/10/03)
Methods for the synthesis of 3-O-(carboxymethyl)- and 3-O-alkylated myo-inositol 1,4,5-trisphosphates in racemic form from myo-inositol have been devised. For DL-3-O-(carboxymethyl)-myo-inositol 1,4,5-trisphosphate, an analogue of myo-inositol 1,3,4,5-tet
Synthesis of (+/-)-3-O-Alkylated Myo-Inositol 1,4,5-Triphosphate Analogues as Potent Receptor Ligands and Enzyme Inhibitors
Liu, Changsheng,Potter, Barry V L
, p. 8457 - 8460 (2007/10/02)
The synthesis of novel analogues of myo-inositol 1,4,5-triphosphate alkylated at the 3-position from myo-inositol is described using a protection/deprotection sequence employing allyl, benzyl and p-methoxybenzyl groups.
SYNTHESIS OF MYO-INOSITOL 1,4,5-TRISPHOSPHATE 3-PHOSPHOROTHIOATE AS AN INHIBITOR OF MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE 3-PHOSPHATASE
Liu, Changsheng,Potter, Barry V. L.
, p. 1605 - 1608 (2007/10/02)
The synthesis of racemic myo-inositol 1,4,5-triphosphate 3-phosphorothioate from myo-inositol is described using a protection/deprotection sequence employing allyl, benzyl and p-methoxybenzyl groups to facilitate selective 3-position thiophosphorylation.
Affinity probes for ins(1,3,4,5)P4 receptors
Estevez, Virginia A.,Prestwich, Glenn D.
, p. 1623 - 1626 (2007/10/02)
A P-1-tethered derivative of Ins(1,3,4,5)P4 was synthesized and used to prepare a bioselective affinity matrix and a photoaffinity label for purification and covalent modification of IP4 receptor proteins.
The synthesis and resolution of (+/-)-1,5,6-tri-O-benzyl-myo-inositol
Desai, Trupti,Fernandez-Mayoralas, Alfonso,Gigg, Jill,Gigg, Roy,Payne, Sheila
, p. 105 - 123 (2007/10/02)
Racemic 1,5,6-O-benzyl-myo-inositol was prepared by five routes and converted into 1,5,6-tri-O-benzyl-2,3-O-isopropylidene-myo-inositol, the camphanates of which were readily separated by chromatography.The absolute configurations of the chiral derivative
