131233-64-2Relevant academic research and scientific papers
Synthesis and in vitro anticancer activity evaluation of novel bioreversible phosphate inositol derivatives
Chen, Wenbin,Deng, Zhaohui,Chen, Kuangyu,Dou, Daolei,Song, Fanbo,Li, Luyuan,Xi, Zhen
supporting information, p. 172 - 181 (2015/03/05)
The chemistry and biology of phosphorylated inositols have become intense areas of research during the last two decades due to their involvement in various cellular signaling processes. However, the metabolic instability by phosphatases or kinases and poo
INOSITOL-BASED MOLECULAR TRANSPORTERS AND PROCESSES FOR THE PREPARATION THEREOF
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Page/Page column 22-23, (2008/06/13)
Inositol derivatives in accordance with the present invention are effective in significantly enhancing the transportation of various therapeutic molecules across a biological membrane, which may include the plasma membrane, nuclear membrane or blood-brain barrier.
Synthesis of all possible regioisomers of scyllo-inositol phosphate
Chung, Sung-Kee,Kwon, Yong-Uk,Chang, Young-Tae,Sohn, Kwang-Hoon,Shin, Jung-Han,Park, Kyu-Hwan,Hong, Bong-Jin,Chung, In-Hee
, p. 2577 - 2589 (2007/10/03)
scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis- diol. The requisite intermediates, scyllo-inositol benzoates were obtained by benzoyl migration or random benzoylation, and phosphorylated to give scyllo- IP(n). (C) 1999 Elsevier Science Ltd.
Synthesis of (±) 1,2-dideoxy-1,2-diamino-myo-inositol
Guedat, Philippe,Spiess, Bernard,Schlewer, Gilbert
, p. 7375 - 7378 (2007/10/02)
Starting from myo-inositol, an isostere, diaminated in positions 1 and 2, was prepared. The key step of the synthesis was the simultaneous inversion of the dimesylate 6 with sodium azide leading to the global retention of the configuration.
Total synthesis of (+)-polyoxin J starting from myo-inositol
Chida,Koizumi,Kitada,Yokoyama,Ogawa
, p. 111 - 113 (2007/10/02)
The total synthesis of the antifungal antibiotic, polyoxin J starting from myo-inositol is described; the two key components, were prepared from a pair of optically resolved myo-inositol derivatives , respectively, using a highly regioselective Baeyer-Vil
INVESTIGATIONS IN THE FIELD OF DERIVATIVES OF ASYMMETRICALLY SUBSTITUTED myo-INOSITOL. XXXVI. SEPARATION OF DIASTEREOMERIC CARBOHYDRATE DERIVATIVES OF myo-INOSITOL BY THE HPLC METHOD
Runova, O. B.,Krylova, V. N.,Shastina, N. S.,Eremin, S. V.,Stepanov, A. E.,Shvets, V. I.
, p. 249 - 257 (2007/10/02)
The possibility has been shown of using the HPLC method for separating diastereomeric compounds of myo-inositol obtained under the conditions of the transesterification of racemic myo-inositol derivatives with D-mannose (ethyl orthoacetate).The optically active myo-inositol derivatives obtained can be used for the synthesis of myo-inositol phosphates with various structures.
Synthesis and Tritium Radiolabelling of Fluorinated Analogues of myo-Inositol
Offer, John L.,Voorheis, H. Paul,Metcalfe, James C.,Smith, Gerry A.
, p. 953 - 960 (2007/10/02)
Syntheses have been developed for a set of six myo-inositol analogues from myo-inositol in which single hydroxy groups have been replaced by fluorine (monodeoxy-fluoro-myo-inositols).Except for 2-deoxy-2-fluoro-myo-inositol 32 and 1D-4-deoxy-4-fluoro-myo-
Total Synthesis of Fluorinated Analogues of Inositol and Inositol 1,4,5-Trisphosphate
Sawyer, Deborah A.,Potter, Barry V. L.
, p. 923 - 932 (2007/10/02)
Syntheses of fluorinated analogues of inositol and inositol 1,4,5-trisphosphate are described. 1-Deoxy-1-fluoro-scyllo-inositol, 2-deoxy-2,2-difluoro-myo-inositol, DL-2-deoxy-2-fluoro-scyllo-inositol 1,4,5-trisphosphate and DL-2-deoxy-2,2-difluoro-myo-ino
The synthesis and resolution of (+/-)-1,5,6-tri-O-benzyl-myo-inositol
Desai, Trupti,Fernandez-Mayoralas, Alfonso,Gigg, Jill,Gigg, Roy,Payne, Sheila
, p. 105 - 123 (2007/10/02)
Racemic 1,5,6-O-benzyl-myo-inositol was prepared by five routes and converted into 1,5,6-tri-O-benzyl-2,3-O-isopropylidene-myo-inositol, the camphanates of which were readily separated by chromatography.The absolute configurations of the chiral derivative
