1312698-60-4

Upstream product

• 23731-06-8 5-(chloromethyl)salicylaldehyde 
• 90-02-8 salicylaldehyde 
• 3328-70-9 5-formyl-2-hydroxybenzaldehyde 
• 138500-85-3 4-bromomethylphenylboronic acid pinacol ester 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 302348-51-2 (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 1169945-44-1 2-(4-(iodomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1312698-61-5 (HO)2BC₆H₄CH₂OC₆H₃(CHCHC₈H₄N(CH₃)2CH₂CH₂CH₂SO₃)2 

Relevant academic research and scientific papers

NIRF turn-on nanoparticles based on the tumor microenvironment for monitoring intracellular protein delivery

A dual responsive NIRF turn-on protein delivery system incorporating an NIRF turn-on probe and protein into one single nanoparticle has been constructed. It can be taken up efficiently by A549 cells, where protein release and NIRF recovery happen simultaneously in response to low pH and excessive H2O2. This work provides a novel system for monitoring intracellular protein delivery.

Design, synthesis and application of a dual-functional fluorescent probe for reactive oxygen species and viscosity

A fluorescence probe based on cyanine fluorophore was designed and synthesized in this work, which can be used to determine viscosity and reactive oxygen species (e.g., OCl?, ONOO?) at different wavelengths. Under a low viscosity med

Simultaneous fluorescence imaging of selenol and hydrogen peroxide under normoxia and hypoxia in HepG2 cells and: In vivo

Based on the rapid substitution reaction of the Au-S bond by selenol, we designed and synthesized a nanoprobe 5-FAM-peptide-AuNPs for selenol. Real-time imaging shows that this probe together with the molecular probe QCy7-H2O2 is able to simultaneously and differentially monitor the concentrations of selenol and H2O2 in living cells and in vivo.

COMPOUNDS AS STIMULI-RESPONSIVE PROBES, METHODS AND APPLICATIONS THEREOF

The present disclosure relates to the field of synthetic pharmaceutical chemistry and biology. The disclosure provides a compound of Formula I and a process of preparation thereof. The disclosure further relates to methods and use of Formula I compounds a

ACTIVATABLE FLUOROGENIC COMPOUNDS AND USES THEREOF AS NEAR INFRARED PROBES

Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in c

A unique paradigm for a turn-ON near-infrared cyanine-based probe: Noninvasive intravital optical imaging of hydrogen peroxide

The development of highly sensitive fluorescent probes in combination with innovative optical techniques is a promising strategy for intravital noninvasive quantitative imaging. Cyanine fluorochromes belong to a superfamily of dyes that have attracted sub