131348-67-9Relevant articles and documents
Stereoselective debromination of vic-dibromides to E-alkenes with dimethylformamide
Khurana,Maikap,Sahoo
, p. 827 - 828 (1991)
A simple and efficient procedure for the quantitative debromination of vic-dibromides to E-alkenes in refluxing dimethylformamide has been described.
Exploration of synthetic antioxidant flavonoid analogs as acetylcholinesterase inhibitors: an approach towards finding their quantitative structure–activity relationship
Karmakar, Abhijit,Ambure, Pravin,Mallick, Tamanna,Das, Sreeparna,Roy, Kunal,Begum, Naznin Ara
, p. 723 - 741 (2019/04/17)
The binding interactions between acetylcholinesterase (AChE) and a series of antioxidant flavonoid analogs were studied by fluorescence spectroscopic assay. The present study incorporated different classes of naturally occurring and synthetic flavonoid compounds like flavones, isoflavones, and chalcones as well as a few standard antioxidants. The AChE inhibitory (AChEI) activity of these compounds was further analyzed using in silico techniques, namely pharmacophore mapping, quantitative structure–activity relationship (QSAR) analysis, and molecular docking studies. We have also compared the AChE inhibitory and radical scavenging antioxidant activities of these compounds. Both the AChE inhibitory and antioxidant activities of these compounds were found to be highly dependent on their structural patterns. However, it was observed that, in general, flavones are comparatively better AChE inhibitors as well as antioxidants compared to chalcones. [Figure not available: see fulltext.].
Copper-catalyzed rearrangement of N-aryl nitrones into epoxyketimines
Mo, Dong-Liang,Anderson, Laura L.
supporting information, p. 6722 - 6725 (2013/07/26)
Please pass the oxygen: A new method for the preparation of trans-α,β-epoxyketimines has been achieved through a copper-catalyzed rearrangement of (E)-α,β-unsaturated nitrones. The scope and tolerance of the method is evaluated and the synthetic utility of the products is demonstrated. The new transformation provides facile access to an unusual, densely functionalized intermediate that can be exploited for further synthetic application. Copyright