13163-77-4

Upstream product

• 3580-38-9 2-Benzoylcyclohexanone 
• 818-57-5 Methyl 4-pentenoate 
• 98-86-2 acetophenone 
• 591-80-0 pent-4-enoic acid 
• 106-95-6 allyl bromide 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 117-99-7 2-Hydroxybenzophenone 
• 1067908-85-3 (E)-1-phenylhepta-4,6-diene-1,3-dione 
• 860774-45-4 (E)-α-(Tetrahydro-5-methyl-2-furylidene)acetophenone 

Relevant academic research and scientific papers

PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN(PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

MgBr2·OEt2-promoted coupling of ketones and activated acyl donors via soft enolization: A practical synthesis of 1,3-diketones

Ketones undergo soft enolization and acylation on treatment with MgBr 2OEt2, i-Pr2NEt, and various acylating agents to give 1,3-diketones. The process is particularly efficient for N-acylbenzotriazoles and O-pentafluorophenyl esters, and, in these cases, is conducted using untreated, reagent grade CH2C12 open to the air, thus providing an exceptionally simple approach to the synthesis of this important class of compounds. Thieme Stuttgart.

Direct carbon - Carbon bond formation via soft enolization: A facile and efficient synthesis of 1,3-diketones

Ketones undergo soft enolate formation and acylation on treatment with MgBr2·OEt2, i-Pr2NEt, and various acylating agents to give 1,3-diketones. The process is particularly efficient for N-acylbenzotriazoles and O-Pfp esters, and, in these cases, is conducted with untreated, reagent-grade CH2Cl2 open to the air, thus providing an exceptionally simple approach to the synthesis of this important class of compounds.

Synthesis of monomeric and polymeric ligands based on β-Diketones

Unsaturated β-diketones with CH3, CF3, and C6H5 groups were synthesized by condensation of unsaturated esters with ketones. The fraction of the enol form of β-diketones was determined and their radical homo-and copolymerization reactions were studied. Styrene and methyl methacrylate copolymers containing β-dicarbonyl fragments were prepared, which can be used as highly efficient reagents for luminescence determination of europium.

PHOTOREACTION OF 2-BENZOYLCYCLOHEXANONES ON A SILICA GEL SURFACE: DEVIATION FROM THEIR SOLUTION PHOTOCHEMISTRY

On irradiation on a dry silica gel surface, 2-benzoylcyclohexanones which have the lowest n, ?* state and are devoid of methyl substituents on their cyclohexanone rings, undergo an oxidative cleavage to give adipic acid and substituted benzoic acid along with the Norrish Type II product.Irradiation of 2-chlorocyclohexanone and cyclohexane-1,2-dione on silica gel gives adipic acid.The cyclohexanoyl radical on the surface, which is produced from the α-cleavage of the 2-benzoyl group of the 2-benzoylcyclohexanones or the cleavage of the C-Cl bond of 2-chlorocyclohexanone, is suggested as the precursor of adipic acid; the radical is probably converted into cyclohexane-1,2-dione, which undergoes a secondary photoreaction to give adipic acid on the surface.

Type II Photoreaction of 2-Benzoylcycloalkanones: Conformational Control in the Biradical Formation and in the Behavior of Biradicals

The photoreactivities of 2-benzoylcycloalkanones were shown to be controlled by their ring conformation; 2-benzoylcycloalkanones underwent the Type II elimination and/or cyclization, and /or the α-cleavage reaction.