13165-83-8

Upstream product

• 1709-60-0 4-methoxybenzenesulfinic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 1350444-88-0 N-(p-methoxyphenylsulfinyl)phthalimide 
• 141-52-6 sodium ethanolate 
• 88683-45-8 2-((4-methoxyphenyl)thio)isoindoline-1,3-dione 
• 696-63-9 4-Methoxybenzenethiol 
• 64-17-5 ethanol 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 

Downstream Products

• 116757-20-1 3-<(4-methoxyphenyl)thio>indole 

Relevant academic research and scientific papers

NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions

We have developed a protocol for the NaHSO3-promoted esterification of sulfonyl hydrazides with alcohols for the synthesis of sulfinic esters. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably undergoes via a radical pathway. (Figure presented.).

Preparation method of sulfinate compound

The invention relates to a preparation method of a sulfinate compound shown as a formula (III), which comprises the following steps: by using a sulfonyl hydrazine compound shown as a formula (I) and alcohol shown as a formula (II) as raw materials, adding

Iodine-catalyzed sulfuration of isoquinolin-1(2H)-ones applying ethyl sulfinates

An efficient sulfuration of isoquinolin-1(2H)-ones at the C-4 position is reported by employing ethyl sulfinates, and the corresponding products are obtained in moderate to excellent yields in the presence of iodine. This synthetic strategy provides a range of thioether-isoquinolin-1(2H)-ones while tolerating a number of functional groups on the isoquinoline nitrogen atom and benzene ring. In addition, pyridin-2(1H)-one is also reacted smoothly and afforded the corresponding thioether product in moderate yield. A plausible mechanism is suggested based on the preliminary mechanistic studies.

Electrochemical Synthesis of Sulfinic Esters via Aerobic Oxidative Esterification of Thiophenols with Alcohols

A method for the electrochemical synthesis of sulfinic esters by aerobic oxidative coupling of thiophenols and alcohols has been developed. Using electrons as the redox reagent and O 2in air as the oxygen source, the reactions proceeded smoothly at room temperature, even for a gram-scale preparation. No use of catalyst, clean redox reagent, green and abundant oxygen source, and mild reaction conditions make this strategy eco-friendl.

Electrochemical synthesis of sulfinic esters from alcohols and thiophenols

Electrochemical oxidative couplings between S[sbnd]H and O[sbnd]H bonds are achieved herein directly from readily-available alcohols and thiophenols, affording a series of diverse sulfinic esters. This strategy can take advantage of 6 equivalents of alcohol, relative to thiophenol, to achieve moderate to good yields, without the assistance of any metallic catalysts, bases, and additional oxidants.

Catalyst-free sulfenylation of indoles with sulfinic esters in ethanol

A novel catalyst-free method for the synthesis of structurally diverse indole thioethers in moderate to excellent yields has been developed. In this reaction, sulfinic esters serve as new sulfur electrophiles.

A sustainable oxidative esterification of thiols with alcohols by a cobalt nanocatalyst supported on doped carbon

Here, we developed a new cobalt nanocatalyst supported on N-SiO2-doped activated carbon (Co/N-SiO2-AC), which exhibits excellent catalytic performance towards the oxidative esterification of (hetero)aryl and alkyl thiols with alcohols. A wide array of sulfinic esters were efficiently afforded in an exclusive chemoselective manner. The developed synthetic method proceeds with the merits of mild reaction conditions, broad substrate scope, operational simplicity, good functional group tolerance, earth-abundant and reusable cobalt catalysts, the utilization of renewable alcohols as the coupling partners and molecular O2 as the sole oxidant, which offers a practical method for sustainable synthesis of sulfinic esters.

Facile aerobic photo-oxidative synthesis of sulfinic esters

A mild and efficient one-pot visible light-induced method has been developed for the synthesis of sulfinic esters. Sulfinic esters are important structural elements that are frequently found in pharmaceutical agents and biologically active natural products. The routine procedure in the drug discovery and development process to prepare and fully characterize sulfinic esters make them a drug candidate for biological evaluation.

Method for preparation of sulfinic acid ester from thiophenol or thiol

The invention discloses a method for preparation of sulfinic acid ester from thiophenol or thiol. The method includes the steps of: 1. oxidative esterification: adding 1 equivalent of thiol or thiophenol into a pressure-tolerant reaction bottle, at the sa

The synthesis of sulfinylphthalimides and their reactions with some nucleophiles in dioxane

In this study, some N-(p-substituted-arylsulfinyl)phthalimides (1a-1e) were synthesized. The synthesized compounds were examined with respect to their substitution reactions with sodium ethoxide, sodium methoxide, methylamine, and t-butylamine in dioxane.