13169-71-6

Usage

Uses

Used in Pharmaceutical Synthesis:
(4-chlorophenyl)(1H-pyrrol-2-yl)methanone is utilized as a key intermediate in the production of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new treatments and therapies.
Used in Organic Chemistry Research:
In the realm of organic chemistry, (4-chlorophenyl)(1H-pyrrol-2-yl)methanone serves as a valuable compound for research purposes. Its reactivity and structural features make it suitable for exploring new chemical reactions and mechanisms, furthering our understanding of organic processes and potentially leading to the discovery of novel chemical entities.
Used in Chemical Intermediates Production:
As a chemical intermediate, (4-chlorophenyl)(1H-pyrrol-2-yl)methanone is employed in the synthesis of other organic compounds. Its role in the production of various chemical intermediates highlights its importance in the broader chemical industry, where it contributes to the creation of a diverse array of products.
Used in Specialty Chemicals Manufacturing:
(4-chlorophenyl)(1H-pyrrol-2-yl)methanone may also find application in the manufacturing of specialty chemicals, where its unique properties can be leveraged to create niche products with specific applications in various industries, such as agriculture, materials science, or environmental management.

Upstream product

• 19202-04-1 N-(4-chlorobenzoyl)morpholine 
• 109-97-7 pyrrole 
• 62128-38-5 (4-chlorophenyl)-(1H-pyrrol-3-yl)methanone 
• 112816-54-3 2-[2-(4-Chloro-phenyl)-benzo[1,3]oxathiol-2-yl]-1H-pyrrole 
• 122-01-0 4-chloro-benzoyl chloride 
• 14989-30-1 hypochloric acid 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 20671-52-7 lithium pyrrolide 
• 104-88-1 4-chlorobenzaldehyde 
• 38480-28-3 2-bromo-1H-pyrrole 
• 873-76-7 para-Chlorobenzyl alcohol 
• 58948-38-2 2-(4-Chlorophenyl)-1,3-benzoxathiolium tetrafluoroborate 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 129055-90-9 [1-(2-Chloromethyl-benzyl)-1H-pyrrol-2-yl]-(4-chloro-phenyl)-methanone 
• 129055-80-7 (1-{2-[2-(4-Chloro-benzoyl)-pyrrol-1-ylmethyl]-benzyl}-1H-pyrrol-2-yl)-(4-chloro-phenyl)-methanone 
• 147088-92-4 [4-(4-Chloro-benzoyl)-1H-pyrrol-2-yl]-(4-chloro-phenyl)-methanone 
• 154047-00-4 (1-Allyl-1H-pyrrol-2-yl)-(4-chloro-phenyl)-methanone 
• 62128-38-5 (4-chlorophenyl)-(1H-pyrrol-3-yl)methanone 
• 86770-47-0 2-(p-chlorobenzyl)pyrrole 
• 154047-16-2 (4-Chloro-phenyl)-(1H-pyrrol-2-yl)-methanol 
• 157847-12-6 2-chloro-1-[5-(4-chlorobenzoyl)-1H-pyrrol-3-yl]ethanone 
• 154047-19-5 (1-Allyl-1H-pyrrol-2-yl)-(4-chloro-phenyl)-methanol 
• 22112-77-2 5,10,15,20-tetra-(4-chlorophenyl)porphyrin 
• 129055-85-2 11-(4-Chloro-phenyl)-5H-benzo[e]pyrrolo[1,2-a]azepine 
• 1528751-57-6 ethyl {2-[(4-chlorophenyl)carbonyl]-1H-pyrrol-1-yl}acetate 

Relevant academic research and scientific papers

Synthesis method of 2-aromatic acyl pyrrole compounds

The invention relates to the field of organic synthesis, and discloses a synthesis method of 2-aromatic acyl pyrrole compounds, wherein the synthesis method comprises the steps: taking an N-aromatic acyl pyrrole compound as a raw material, and carrying ou

Pyrrole isoquinoline aggregation-induced fluorescent molecular probe as well as preparation and application thereof

The invention provides a pyrrole isoquinoline aggregation-induced fluorescent molecular probe as well as preparation and application thereof. The synthesis method of the pyrrole isoquinoline derivative is simple, and the synthesized fluorescent probe has

Method for synthesizing drug intermediate pyrrolidone compound

The invention relates to a method for synthesizing a pyrrolidone compound which can be used as a drug intermediate as shown in a formula (III). The method comprises the following steps: reacting a compound as shown in a formula (I) with a compound as shown in a formula (II) in the presence of a catalyst, an organic ligand, an oxidant, an adjuvant and alkali in an organic solvent under a nitrogen atmosphere, and performing post-treatment after the reaction is completed to obtain the compound as shown in the formula (III), wherein R is H, C1-C6 alkyl, C1-C6 alkoxy, halogen or nitro. According to the method, a comprehensive reaction system of catalyst, ligand, oxidant, alkali and solvent is adopted, so that a target product is obtained with high yield. The pyrrolidone compound has an excellent application prospect and industrial production potential in the technical field of organic synthesis, especially drug intermediate synthesis.

Synthesis of 2-benzoylpyrrole derivatives via C-H functionalization adjacent to nitrogen of pyrrole

A direct transition-metal-free synthesis of 2-benzoylpyrrole derivatives from free (N-H) pyrroles and benzaldehyde has been developed. The benzoylation reaction at the 2 or 5-position of pyrrole proceeded well under the alkali metalation system and with 2

Synthesis of a new compound family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5] triazepin-4(5H)-ones

Representatives of a new family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin- 4(5H)-ones have been synthesized at our laboratory as bioisosters of biologically active 1-aryl-2,3-benzodiazepine-4-ones. The efficient synthetic route described applies the synth

Solvent free synthesis of 2-acylpyrroles and its derivatives catalysed by reuseable zinc oxide

A highly efficient procedure for preparing 2-acylpyrroles and its derivatives is described. The products were obtained through regioselective Friedel-Crafts reactions of pyrroles and its derivatives with alkyl or aryl acid chlorides catalysed by zinc oxide under solvent-free conditions. This method has the advantages of green chemistry, operational simplicity, solvent-free conditions, and recoverable catalyst.

A novel one-pot synthesis of 2-benzoylpyrroles from benzaldehydes

We herein report a novel one-pot reaction for benzoylation of pyrrole. The key step in the reaction is generation of di(1H-pyrrol-1-yl)zirconium(IV) chloride complex which reacts with benzaldehydes and methyl benzoates to give 2-benzoylpyrroles as the major product.

Infrared and Nuclear Magnetic Resonance Properties of Benzoyl Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

Benzophenones, 2-benzoylthiophenes, 2-benzoylpyrroles, and 2-benzoylfurans, which have substituents at m- and p-positions of the benzoyl ring were prepared and their ir and nmr spectra were obtained in 0.1 M chloroform-d solution. The chemical shift values of each series were plotted against the Hammett substituent parameters to give good correlation, with the exception of the ortho-Hs and -Cs. The slopes as well as the differences in chemical shift gave sets of meaningful values for the indices of aromaticy.

Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents

2-Aroyl-4-(ω-aminoacyl)- (4) and 4-aroyl-2-(ω-aminoacyl)pyrroles (9) represent a new, structurally novel class of anticonvulsant agents. Compounds of type 4 were prepared by Friedel-Crafts acylation of a 2-aroylpyrrole with an ω-chloroacyl chloride followed by displacement of the chloro group by a primary or secondary amine. Compounds of type 9 were prepared by Friedel- Crafts aroylation of a 2-(ω-chloroacyl)pyrrole followed by displacement by an amine. These compounds were active in the mouse and rat maximal electroshock tests but not in the mouse metrazole test. The lead compound, RWJ-37868, 2-(4-chlorobenzoyl)-4-(1-piperidinyl-acetyl)-1,3,5- trimethylpyrrole (4d), showed potency and therapeutic index comparable to those of phenytoin and carbamazepine and greater than those of sodium valproate. This compound blocked bicuculline induced seizures, did not elevate seizure threshold following iv infusion of metrazole, and blocked influx of Ca2+ ions into cerebellar granule cells induced by K+ or veratridine.

Antifungal agents, II: Synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methane derivatives with unsaturated chains

The synthesis and antifungal activities of aryl-1H-pyrrol-2-yl-1H-imidazol-1-yl-methanes having allyl, crotyl, and acrylate chains linked to the N-pyrrole atom and substituted at phenyl ring by Cl, F, CH3, and NO2 groups are reported