13169-71-6Relevant articles and documents
Synthesis method of 2-aromatic acyl pyrrole compounds
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Paragraph 0025-0028; 0045-0048, (2021/06/12)
The invention relates to the field of organic synthesis, and discloses a synthesis method of 2-aromatic acyl pyrrole compounds, wherein the synthesis method comprises the steps: taking an N-aromatic acyl pyrrole compound as a raw material, and carrying ou
Method for synthesizing drug intermediate pyrrolidone compound
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Paragraph 0050; 0051; 0052; 0053; 0054, (2016/10/27)
The invention relates to a method for synthesizing a pyrrolidone compound which can be used as a drug intermediate as shown in a formula (III). The method comprises the following steps: reacting a compound as shown in a formula (I) with a compound as shown in a formula (II) in the presence of a catalyst, an organic ligand, an oxidant, an adjuvant and alkali in an organic solvent under a nitrogen atmosphere, and performing post-treatment after the reaction is completed to obtain the compound as shown in the formula (III), wherein R is H, C1-C6 alkyl, C1-C6 alkoxy, halogen or nitro. According to the method, a comprehensive reaction system of catalyst, ligand, oxidant, alkali and solvent is adopted, so that a target product is obtained with high yield. The pyrrolidone compound has an excellent application prospect and industrial production potential in the technical field of organic synthesis, especially drug intermediate synthesis.
Synthesis of a new compound family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5] triazepin-4(5H)-ones
Milen, Mátyás,ábrányi-Balogh, Péter,Dancsó, András,Simig, Gyula,Volk, Balázs
, p. 465 - 476 (2014/01/06)
Representatives of a new family, 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin- 4(5H)-ones have been synthesized at our laboratory as bioisosters of biologically active 1-aryl-2,3-benzodiazepine-4-ones. The efficient synthetic route described applies the synth