14062-80-7

Usage

Uses

Used in Organic Synthesis:
4-chloro-N,N-dimethylbenzamide is utilized as a key intermediate in the synthesis of various organic compounds, contributing to the formation of diverse chemical structures and properties.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4-chloro-N,N-dimethylbenzamide serves as a precursor for the development of new drugs, playing a crucial role in medicinal chemistry and drug discovery processes.
Used as a Reagent in Chemical Reactions:
4-chloro-N,N-dimethylbenzamide is employed as a reagent in various chemical reactions, facilitating specific transformations and contributing to the advancement of chemical research and development.
Used in Pesticide Production:
4-chloro-N,N-dimethylbenzamide is also used as a precursor in the production of pesticides, highlighting its importance in the agrochemical industry for developing effective and safe pest control solutions.
It is essential to store and use 4-chloro-N,N-dimethylbenzamide in a well-ventilated area with appropriate personal protective equipment to ensure safety during handling and application.

InChI:InChI=1/C9H10ClNO/c1-11(2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 124-40-3 dimethyl amine 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 74-11-3 para-chlorobenzoic acid 
• 1624-01-7 tetrakis(dimethylamino)silane 
• 104-88-1 4-chlorobenzaldehyde 
• 4375-83-1 tris(dimethylamino)borane 
• 104-86-9 4-chlorobenzylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 106-43-4 para-chlorotoluene 
• 506-59-2 N,N-dimethylammonium chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 873-73-4 4-n-chlorophenylacetylene 
• 1073-67-2 4-vinylbenzyl chloride 

Downstream Products

• 66417-90-1 3-(4-chloro-phenyl)-7-methyl-4,5,6,7-tetrahydro-benzo[c]isoxazole 
• 72169-19-8 [(4-Chloro-phenyl)-trichlorosilanyl-methyl]-dimethyl-amine 
• 62128-32-9 (4-chlorophenyl)(1-methyl-1H-pyrrol-2-yl)methanone 
• 63833-36-3 5-(4-chloro-benzoyl)-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester 
• 52817-93-3 1-(4-chloro-phenyl)-3,5-dihydro-pyridazino[4,5-b]indol-4-one 
• 129403-29-8 4'-chloro-α,β-difluorochalcone 
• 107115-63-9 isopropyl 5-p-chlorobenzoyl-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 
• 104703-17-5 Ethyl 2-(3-p-Chlorobenzoyl-1-methylindole)acetate 
• 80965-02-2 2-(methylthio)-4-chloro-5-(4-chlorobenzoyl)pyrrole 
• 66635-81-2 isopropyl 5-p-chlorobenzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 
• 90016-91-4 1-(4-Chloro-phenyl)-5-methyl-3,5-dihydro-pyridazino[4,5-b]indol-4-one 
• 121193-01-9 [5-(4-Chloro-benzoyl)-1-methyl-4-methylsulfanyl-1H-pyrrol-2-yl]-acetic acid ethyl ester 
• 186752-47-6 4-chloro-2-(4-chlorophenyl)-5,6-dihydrobenzo[h]quinazoline 
• 15184-98-2 N,N-dimethyl-4-chlorobenzylamine 

Relevant academic research and scientific papers

Metal-free one-pot oxidative amination of aldehydes to amides

Metal-free oxidative amination of aromatic aldehydes in the presence of TBHP provides convenient access to amides in 85-99% under mild reaction conditions within 5 h. This method avoids free carboxylic acid intermediates and integrates aldehyde oxidation and amide bond formation, which are usually accomplished separately, into a single operation. Proline-derived amides can be prepared in excellent yields without noticeable racemization.

One-pot synthesis of a highly disperse core-shell CuO-alginate nanocomposite and the investigation of its antibacterial and catalytic properties

In this study, sodium alginate was extracted from Sargassum algae, collected from coastal waters of Bushehr, Persian Gulf, Iran and used as a stabilizing and wrapping agent for CuO nanoparticles. The synthesized nanocomposite was characterized by some spectroscopic and microscopic techniques, such as IR, XRD, Uv-vis, BET, BJH, zeta potential, SEM, TEM, HR-TEM, and XPS. The antibacterial effects of the CuO-alginate nanocomposite against some bacteria, isolated from a burn wound, were evaluated. The results showed that this nanocomposite had better antibacterial effects than its components onPseudomonas aeruginosaATCC 27853,Staphylococcus aureusATCC 12600,Streptococcus pyogenesATCC 19615, andStaphylococcus epidermidisATCC 49461. Among these,Staphylococcus aureusATCC 12600 was the most sensitive one to this nanocomposite, with the lowest minimum inhibitory concentration (2.08 mg mL?1) observed. Moreover, the synthesized nanocomposite showed good catalytic activity in the oxidative coupling of carboxylic acids withN,N-dialkylformamides toward the synthesis of amides.

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyl disiloxane (DPDS)

A convenient procedure for the chemoselective reduction of tertiary amides at room temperature in the presence of air and moisture using 1,3-diphenyldisiloxane (DPDS) is developed. The reaction conditions tolerate a significant number of functional groups including esters, nitriles, secondary amides, carbamates, sulfoxides, sulfones, sulfonyl fluorides, halogens, aryl-nitro groups, and arylamines. The conditions reported are the mildest to date and utilize EtOAc, a preferred solvent given its excellent safety profile and lower environmental impact. The ease of setup and broad chemoselectivity make this method attractive for organic synthesis, and the results further demonstrate the utility of DPDS as a selective reducing agent.

Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides

We report a simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides. The combined visible light and base system is used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides, and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds are tolerated.

Visible-Light Photoredox-Catalyzed Amidation of Benzylic Alcohols

A new photocatalyzed route to amides from alcohols and amines mediated by visible light is presented. The reaction is carried out in ethyl acetate as a solvent. Ethyl acetate can be defined a green and bio-based solvent. The starting materials such as the energy source are easily available, stable, and inexpensive. The reaction has shown to be general and high yielding.

Novel hetero-cyclic compound and organic light emitting device comprising the same

The present invention relates to a novel heterocyclic compound capable of increasing efficiency, low driving voltage and/or lifetime characteristics in an organic light emitting device, and an organic light emitting device using the same. The novel heterocyclic compound is represented by chemical formula 1. In chemical formula 1, L is phenylene, biphenylylene, or naphthylene, and Xs are each independently N or CH, wherein at least one of Xs is N.COPYRIGHT KIPO 2019

Novel hetero-cyclic compound and organic light emitting device comprising the same

The present invention relates to a novel heterocyclic compound capable of enhancing efficiency, and low driving voltage and/or lifespan characteristics in an organic light emitting device, and to an organic light emitting device using the same. The novel heterocyclic compound is represented by chemical formula 1. In chemical formula 1, Xs are each independently N or CH, wherein at least one of Xs is N, L_1 is a bond or substituted or unsubstituted C_(6-60) arylene.COPYRIGHT KIPO 2019

Novel hetero-cyclic compound and organic light emitting device comprising the same

The present invention refers to novel heterocyclic compounds and organic light emitting device using the same number [...] substrate. (by machine translation)