13196-11-7Relevant articles and documents
PD-1/PD-L1 small-molecule inhibitor and preparation method and application thereof
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, (2019/05/08)
The invention discloses a PD-1/PD-L1 small-molecule inhibitor and a preparation method and application thereof. Specifically, the invention discloses a compound with the structure shown in the formulaL, a stereoisomer or a tautomer thereof, or pharmaceutically acceptable salts or hydrates or solvates thereof, and please see the specification for specific definitions. The compound has excellent effects for restraining PD-1/PD-L1. Please see the specification for the formula.
HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF
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Paragraph 00395, (2018/02/28)
Described herein are compounds, including pharmaceutically acceptable salts thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat, prevent or diagnose blood-based diseases, disorders or conditions.
Concise synthesis of 6-cyanobenzo[ b ]furan, a useful building block
Nguyen, Son T.,Williams, John D.,Majgier-Baranowska, Helena,Li, Bing,Neelagiri, Venugopal R.,Kim, Hwa-Ok,Peet, Norton P.
, p. 1307 - 1313 (2014/04/17)
A new three-step synthesis of 6-cyanobenzo[b]furan (6) was developed, starting from commercially available 6-hydroxybenzo[b]furan-3-one (18). Key steps in this process were the first step, which was the reductive dehydration of 18 to produce 6-hydroxybenzo[b]furan (19), and the last step, which converted the aryl triflate 20 to the aryl cyanide 6 in a palladium-catalyzed cross-coupling protocol. Overall yield for this new synthesis was 49%.
