1627-20-9Relevant academic research and scientific papers
Synthesis of furanochromones: A new step in improvement of fluorescence properties
Klymchenko, Andrey S.,Ozturk, Turan,Demchenko, Alexander P.
, p. 7079 - 7082 (2002)
New 3-hydroxychromone derivatives with a fused furan heterocycle (2-aryl-3-hydroxyfurano[3,2-g]chromones) have been synthesized. This was achieved by an important improvement in the synthetic procedure. Like their parent analogs, these new compounds exhibit two intensive fluorescence emission bands belonging to normal (N*) and tautomer (T*) excited-state forms. While the spectral position of the N* band remains unchanged, the T* band is shifted to longer wavelengths, providing larger separation between the two bands. The new compounds exhibit increased molecular extinction and, more importantly, have about twice as high fluorescence quantum yields. These properties make them very promising for designing new two-band fluorescence sensors.
TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS
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Paragraph 0121; 0123, (2021/07/17)
The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (1) or a pharmaceutically acceptable salt thereof.
Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents
China Raju,Nageswara Rao,Suman,Yogeeswari,Sriram,Shaik, Thokhir Basha,Kalivendi, Shasi Vardhan
scheme or table, p. 2855 - 2859 (2011/06/24)
Series of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 7a-7zb, 8a-8d and 9a-9d were synthesized and screened for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) and cytotoxicity against three human cancer cell lines including A549, SK-N-SH and HeLa. The results indicate that six compounds are more potent and 7za is most effective anti-mycobacterial derivative compared to the standard drugs Ethambutol and Ciprofloxacin. However, 12 compounds exhibited cytotoxicity against human neuroblastoma cell line; amongst them the compound 7v is most effective compared to the standard drug Doxorubicin. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5- carboxylates.
Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors
Dixit, Manish,Tripathi, Brajendra K.,Tamrakar, Akhilesh K.,Srivastava, Arvind K.,Kumar, Brijesh,Goel, Atul
, p. 727 - 734 (2007/10/03)
Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in m
A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers
Dixit, Manish,Sharon, Ashoke,Maulik, Prakas R.,Goel, Atul
, p. 1497 - 1502 (2007/10/03)
Benzofurans functionalized with hydroxy and acetyl functionalities are not only the core structures found in a large number of biologically important natural products, but also the vital precursors for several naturally occurring furanoflavonoids. Numerou
Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.
Anuradha,Srinivas, Pullela V.,Ranga Rao,Manjulatha,Purohit, Muralidhar G.,Madhusudana Rao
, p. 6820 - 6826 (2007/10/03)
Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4″,5″,6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa. Chrysophanol, calodenone, lophirone A and lophirone H were isolated from this plant for the first time. The structures of all the isolated compounds were confirmed by 1D and 2D spectroscopic data. These compounds were tested for analgesic and anti-inflammatory activity. All the new compounds showed good analgesic and anti-inflammatory activity. A simple and facile method for the cleavage of benzyl ethers using I2 in trigol is also reported.
Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors
Dixit, Manish,Tripathi, Brajendra K.,Srivastava, Arvind K.,Goel, Atul
, p. 3394 - 3397 (2007/10/03)
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in mu
Amberlyst 15-catalyzed efficient synthesis of 5-acetyl-4-hydroxy-coumarone and 5-acetyl-6-hydroxy-coumarone: Crucial precursors for several naturally occurring furanoflavones
Goel, Atul,Dixit, Manish
, p. 1990 - 1994 (2007/10/03)
A novel approach to the total synthesis of naturally occurring furanoflavones and furanochalcones is described. Angular and linear furanoflavones and furanochalcones have been prepared in just four steps, using economical reagents and simple reaction cond
