66486-61-1

Basic information

• Product Name: 7H-Furo[3,2-g][1]benzopyran-7-one, 5-phenyl-
• CAS NO: 66486-61-1
• Molecular Formula: C17H10O3
• Molecular Weight: 262.265
• Mol File: 66486-61-1.mol

Chemical Properties

• CAS DataBase Reference: 7H-Furo[3,2-g][1]benzopyran-7-one, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Furo[3,2-g][1]benzopyran-7-one, 5-phenyl-(66486-61-1)
• EPA Substance Registry System: 7H-Furo[3,2-g][1]benzopyran-7-one, 5-phenyl-(66486-61-1)

Safety Data

• Hazardous Substances Data: 66486-61-1(Hazardous Substances Data)

Upstream product

• 93327-71-0 5-phenyl-2,3-dihydro-furo[3,2-g]chromen-7-one 
• 13196-11-7 6-hydroxybenzofuran 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 2555-30-8 7-hydroxy-4-phenylcoumarin 
• 74794-33-5 7-hydroxy-8-iodo-4-phenyl-2H-1-benzopyran-2-one 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 76463-91-7 7-allyloxy-8-iodo-4-phenyl-2H-1-benzopyran-2-one 
• 96853-42-8 4-(2-Nitroethyl)benzene-1,3-diol 
• 96853-35-9 5-Hydroxy-2-(2-nitroethenyl)-phenol 
• 85878-59-7 6-acetoxy-2,3-dihydrobenzofuran 

Relevant articles and documents

Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study

Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of 1a were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 μg/mL) than 1a (MIC = 6.25 μg/mL), and is even potent than the positive control metronidazole (MIC = 0.50 μg/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of 1a have also led to an outline of structure-activity relationship.

A new efficient method for the total synthesis of linear furocoumarins

A new efficient method for the synthesis of linear furocoumarins by a Nef reaction and intramolecular cyclocondensation in one pot results in the construction of a benzofuran ring. This method provides a new strategy to furnish the benzofuran framework easily, and also allows the convenient synthesis of furocoumarin derivatives with different substituents on the coumarin ring by a subsequent Pechmann reaction. This strategy has also been applied to the preparation of four additional benzofuran derivatives. Georg Thieme Verlag Stuttgart.

A Convenient Synthesis of Psoralen Derivatives: Psoralen, 4-Methyl-psoralen and 4-Phenyl-psoralen

A convenient synthesis of psoralen derivatives, viz., 7H-furo benzopyran-7-one (psoralen), 5-methyl-7H-furo benzopyran-7-one (4-methyl-psoralen) and 5-phenyl-7H-furo benzopyran-7-one (4-phenyl-psoralen) by blocking the 8-position of the starting compounds with iodine, subsequent Claisen migration followed by cyclisation is described. - Keywords: Claisen migration; Coumarins; Psoralen derivatives