13229-03-3

Basic information

• Product Name: 2-hydrazinyl-5-phenyl-1,3,4-thiadiazole
• CAS NO: 13229-03-3
• Molecular Formula: C₈H₈N₄S
• Molecular Weight: 192.2409
• Mol File: 13229-03-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 375.7°C at 760 mmHg
• Flash Point: 181°C
• Density: 1.4g/cm³
• Vapor Pressure: 7.64E-06mmHg at 25°C
• Refractive Index: 1.714
• CAS DataBase Reference: 2-hydrazinyl-5-phenyl-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydrazinyl-5-phenyl-1,3,4-thiadiazole(13229-03-3)
• EPA Substance Registry System: 2-hydrazinyl-5-phenyl-1,3,4-thiadiazole(13229-03-3)

Safety Data

• Hazardous Substances Data: 13229-03-3(Hazardous Substances Data)

Upstream product

• 86738-35-4 2-(methylsulfonyl)-5-phenyl-1,3,4-thiadiazole 
• 49580-00-9 2-benzylidene-1-(5-phenyl-1,3,4-thiadiazol-2-yl)hydrazine 
• 53645-95-7 2-bromo-5-phenyl-1,3,4-thiadiazole 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 93-58-3 benzoic acid methyl ester 
• 613-94-5 benzoic acid hydrazide 
• 5585-19-3 5-phenyl-1,3,4-thiadiazole-2-thiol 
• 65-85-0 benzoic acid 
• 6956-33-8 dibenzylidenethiocarbohydrazide 
• 100-52-7 benzaldehyde 
• 1627-73-2 1-benzylidene thiosemicarbazide 
• 13373-11-0 2-chloro-5-phenyl-[1,3,4]thiadiazole 
• 49579-94-4 nitroso-(5-phenyl-[1,3,4]thiadiazol-2-yl)-amine 

Downstream Products

• 91096-51-4 3-(phenyl-[1,3,4]thiadiazol-2-yl)-dithiocarbazic acid benzyl ester 
• 473725-40-5 N-cyclohexylidene-N'-(5-phenyl-[1,3,4]thiadiazol-2-yl)-hydrazine 
• 901788-26-9 (Z)-3-phenyl-2-[(5-phenyl-[1,3,4]thiadiazol-2-yl)-hydrazono]-propionic acid 
• 901788-25-8 (E)-3-phenyl-2-[(5-phenyl-[1,3,4]thiadiazol-2-yl)-hydrazono]-propionic acid 
• 106477-33-2 C₁₅H₁₁N₅O₂S 
• 1186014-24-3 C₁₆H₁₄N₄OS 
• 1428638-18-9 4-methyl-2-(5-phenyl-1-(5-phenyl-1,3,4-thiadiazol-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol 
• 1428638-15-6 4-chloro-2-(5-phenyl-1-(5-phenyl-1,3,4-thiadiazol-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol 
• 1274816-44-2 C₂₃H₂₈N₄OS 

Relevant articles and documents

Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues

The synthesis of the new powerful trypanocidal agent brazilizone A (4k) (IC50/24 h = 5.3 μM) is reported. In this work we reported the synthesis and the trypanocidal profile of new 1,3,4-thiadiazole-2-arylhydrazone derivatives of nitroimidazole

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazolylpyrazolines Compounds Containing Ferrocene

The synthesis of 1,3,4-thiadiazole skeleton compounds exhibiting high fungicidal activities has been demonstrated. Thirteen novel 1,3,4-thiadiazolyl-pyrazolines compounds containing ferrocene were designed and synthesized from the ferrocenylchalcones intermediates 3a–3m and the 2-hydrazino-5-phenyl-1,3,4-thiadiazole intermediate 8. All compounds were characterized by 1H NMR, 13C NMR, FT-IR spectra, and HR-MS, and the structure of one of the new compounds N-(4-phenyl-1,3,4-thiadiazol-2-yl)-3-ferrocenyl-5-phenyl-pyrazoline 9a was further determined by X-ray diffraction analysis. The preliminary results of a biological activity assay indicated that all the title compounds exhibited significant fungicidal activities against Pythium solani, Gibberella saubinetii, and Gibberella nicotiancola. Furthermore, compounds 9e and 9h displayed even higher fungicidal activities against the three fungal species compared with the control drug pyraclostrobin.

Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione

(Chemical Equation Presented) Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino- 5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2, 3-dione. All these comple