132575-63-4

Usage

Uses

Used in Organic Synthesis:
(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one is used as a building block for the synthesis of more complex organic molecules, leveraging its unique cyclic structure and functional groups to create a variety of compounds with different properties and applications.
Used in Pharmaceutical Industry:
As a chiral molecule, (3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one may be utilized in the development of pharmaceuticals, where its specific stereochemistry could play a crucial role in the compound's biological activity and selectivity towards target proteins or enzymes.
Used in Research and Development:
(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyldihydro-3aH-cyclopenta[d][1,3]dioxol-4(5H)-one serves as a valuable research tool for studying the effects of stereochemistry on molecular interactions and reactivity. It can be used to investigate asymmetric synthesis, enzymatic reactions, and the development of new methodologies for the production of enantiomerically pure compounds.

Upstream product

• 67-56-1 methanol 
• 115509-13-2 (3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 1056473-59-6 (3a,6aS)-6-hydroxy-2,2-dimethylperhydrofuro[3,4-d][1,3]dioxol-4-one 
• 369647-25-6 (1S,2S,3R)-(-)-1-(2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-(S)-2-propen-1-ol 
• 683276-44-0 (4R,5S)-4,5-O-isopropylidenecyclopenten-1-ol 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 141436-58-0 (-)-(1R)-1-[(4R,5S)-5-((1S)-1-hydroxyallyl)-2,2-dimethyl[1,3]dioxolan-4-yl]ethane-1,2-diol 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 

Downstream Products

• 180524-79-2 Phosphoric acid diphenyl ester (1R,2R,3S,4S)-2,3,4-trihydroxy-cyclopentylmethyl ester 
• 180524-78-1 Phosphoric acid (3aR,4R,6S,6aS)-6-hydroxy-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylmethyl ester diphenyl ester 
• 153527-75-4 C₂₀H₂₀O₆ 
• 153527-74-3 C₂₃H₂₄O₆ 
• 145307-55-7 (2S,3R,4R)-4-t-butyldimethylsiloxymethyl-2,3-isopropylidenedioxycyclopentanone 
• 85026-59-1 (-)-(1R,2R,3S,4R)-4-amino-2,3-dihydroxy-1-(hydroxymethyl)cyclopentane 
• 113299-31-3 (1S,2S,3R,4R)-(+)-4-(Hydroxymethyl)cyclopentane-1,2,3-triol 

Relevant academic research and scientific papers

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

Tumor immunity compound and application thereof

Disclosed are a tumor immunity compound and an application thereof. The invention discloses a compound as shown in the formula (I), optical isomers thereof, and pharmaceutically acceptable salts thereof, and an application of the compound as an STING agonist.

A General Biomimetic Hetero-Diels-Alder Approach to the Core Skeletons of Xenovulene A and the Sterhirsutins A and B

A biomimetic, regio- and stereoselective approach to the 5,6,11-tricyclic core skeleton of xenovulene A, as well as sterhirsutins A and B, is described. The key steps are a biomimetic inverse-electron-demand hetero-Diels-Alder cycloaddition of α-humulene and a ribose-derived vinyl ketone, followed by acid-catalyzed rearrangement of the 1,3-dioxolane that neighbors the resultant cyclic enol ether.

Carbocyclic analogues of D-ribose-5-phosphate: Synthesis and behavior with 5-phosphoribosyl α-1-pyrophosphate synthetases

The synthesis of cyclopentyl and cyclopentenyl analogues of the α- anomer of D-ribose-5-phosphate from D-ribonolactone and D-ribose is described. These analogues, which have the same absolute configuration as D- ribose-5-phosphate, were incubated with PRPP synthetases in an attempt to prepare the corresponding carbocyclic PRPP analogues. The carbocyclic ribose- 5-phosphate analogues were found to be inhibitors, rather than substrates, for 5-phosphoribosyl α-1-pyrophosphate synthetases of both bacterial and human origin. The inhibitory behavior of the analogues is described.

Synthesis of 1α-Pyrophosphoryl-2α,3α-dihydroxy-4β-cyclopentanemethanol-5-phosphate, a Carbocyclic Analog of 5-Phosphoribosyl-1-pyrophosphate (PRPP)

5-Phosphoribosyl-1-pyrophosphate- (PRPP) is a key intermediate in a variety of important metabolic pathways.A total synthesis of the cyclopentyl analog of PRPP has been accomplished.A formal total synthesis of the enantiomer of this analog whose absolute

BIOSYNTHESIS OF ARISTEROMYCIN: EVIDENCE FOR THE INTERMEDIACY OF A 4β-HYDROXYMETHYL-1α,2α,3α-TRIHYDROXYCYCLOPENTANETRIOL.

Evidence for the intermediacy of a 4β-hydroxymethyl-1α,2α,3α-trihydroxycyclopentanetriol (5 or 6) in the biosynthesis of the nucleoside antibiotic aristeromycin (1) has been obtained by administration of doubly-labeled forms of D-glucose to the fermentation broth of Streptomyces citricolor followed by trapping of the tetrol 5 using isotope dilution methods.