13287-64-4Relevant articles and documents
Supramolecular Catalysis of Acyl Transfer within Zinc Porphyrin-Based Metal-Organic Cages
Li, Lili,Yang, Linlin,Li, Xuezhao,Wang, Jing,Liu, Xin,He, Cheng
supporting information, p. 8802 - 8810 (2021/06/28)
To illustrate the supramolecular catalysis process in molecular containers, two porphyrinatozinc(II)-faced cubic cages with different sizes were synthesized and used to catalyze acyl-transfer reactions between N-acetylimidazole (NAI) and various pyridylcarbinol (PC) regioisomers (2-PC, 3-PC, and 4-PC). A systemic investigation of the supramolecular catalysis occurring within these two hosts was performed, in combination with a host-guest binding study and density functional theory calculations. Compared to the reaction in a bulk solvent, the results that the reaction of 2-PC was found to be highly efficient with high rate enhancements (kcat/kuncat = 283 for Zn-1 and 442 for Zn-2), as well as the different efficiencies of the reactions with various ortho-substituted 2-PC substrates and NAI derivates should be attributed to the cages having preconcentrated and preoriented substrates. The same cage displayed different catalytic activities toward different PC regioisomers, which should be mainly attributed to different binding affinities between the respective reactant and product with the cages. Furthermore, control experiments were carried out to learn the effect of varying reactant concentrations and product inhibition. The results all suggested that, besides the confinement effect caused by the inner microenvironment, substrate transfer, including the encapsulation of the reactant and the release of products, should be considered to be a quite important factor in supramolecular catalysis within a molecular container.
Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
-
, (2008/06/13)
Substituted triazolo-pyridazine derivative compounds represented by wherein the variables are disclosed herein are selective ligands for GABA-A receptors, particularly for the α2 and/or α3 subunits.
Triazolopyridines. Part 6. Ring Opening Reactions of Triazolopyridines
Jones, Gurnos,Mouat, Deborah J.,Tonkinson, Daryl J.
, p. 2719 - 2724 (2007/10/02)
The triazole ring in 1,2,3-triazolo-pyridines and -quinolines, and in 1,2,3-triazoloisoquinolines can be opened with loss of nitrogen.The reagents described are bromine, aqueous sulphuric acid, glacial acetic acid, and selenium dioxide; the products from the triazolopyridines are dibromomethyl, hydroxymethyl, acetoxymethyl, and acyl derivatives of pyridine.The generality of the reactions is discussed.The first reported reaction in which the six-membered ring of a 1,2,3-triazolopyridine is opened, by hydride reduction, gives a triazolylbutadiene.