133149-48-1

Upstream product

• 39145-31-8 2-cyano-3-(4-methoxyphenyl)thioacrylamide 
• 118-92-3 anthranilic acid 
• 133149-53-8 (Z)-2-Cyano-3-(4-methoxy-phenyl)-thioacrylimidic acid methyl ester 
• 622847-77-2 2-(4-oxo-3,4-dihydro-2-quinazolinyl)-2-(tetrahydro-2-furanylidene)acetonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 30750-23-3 2-(4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile 

Downstream Products

• 133149-61-8 9-Amino-8-benzoyl-7-(4-methoxy-phenyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carbonitrile 
• 133149-65-2 7-(4-Methoxy-phenyl)-9,11-dioxo-8,11-dihydro-9H-pyrido[2,1-b]quinazoline-6,8-dicarbonitrile 
• 133149-57-2 9-Amino-7-(4-methoxy-phenyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-6,8-dicarbonitrile 

Relevant academic research and scientific papers

Reaction of 2-hetaryl-2-(tetrahydro-2-furanylidene)acetonitriles with aldehydes

The reaction of 2-hetaryl-2-(tetrahydro-2-furanylidene)acetonitriles with a electrophilic reagent (anisaldehyde) was studied. It was shown that condensation of the latter with 2-(4-oxo-3,4-dihydro-2-quinazolyl)- and 2-(1H-benzo[d]imidazol-2-yl)-2-(tetrahydro-2-furanylidene)acetonitriles in the presence of secondary amines or acids takes place with elimination of the furan fragment and the formation of 3-aryl-2-(4-oxo-3,4-dihydro-2-quinazolinyl)- and 2-(1H-benzo[d]imidazol-2-yl)acrylo-nitriles.

α-Cyanothioacetamide and its Derivatives in Heterocyclic Synthesis: Preparation of Several New 4-Oxoquinazoline Derivatives

The reaction of α-cyanothioacetamide (1) or its methylthio derivative (2) with anthranilic acid led to the formation of 3,4-dihydro-4-oxoquinazolin-2-yl acetonitrile (3). 3 condensed with aromatic aldehydes to give arylidene derivatives (4a-d) which could be prepared also via the reaction of 2-thiocarbamoylcinnamonitriles (5a-d) or their methylthio derivatives (6a-d) with anthranilic acid. 3 reacted with cinnamonitrile derivatives (7a-h) and (12a-d) to yield pyrido--quinazoline derivatives (10a-h) and (15a-d) which could also be prepared by the reaction of (4a-d) with malononitrile (11a), benzoyl acetonitrile (11b) and ethylcyanoacetate (16), respectively.