133156-36-2

Upstream product

• 24131-31-5 3,5-dibenzyloxybenzyl alcohol 
• 100-52-7 benzaldehyde 
• 1269415-88-4 (E)-1,3-bis(methoxymethoxy)-5-styrylbenzene 
• 817592-71-5 {[3,5-bis(methoxymethoxy)phenyl]methyl}phosphonic acid diethyl ester 
• 14531-52-3 dihydropinosylvin 
• 107-30-2 chloromethyl methyl ether 
• 67093-27-0 3,5-dibenzyloxybenzyl chloride 
• 33617-49-1 diethyl <3,5-bis(benzyloxy)benzyl>phosphonate 

Downstream Products

• 1262119-77-6 C₂₈H₃₈O₅ 
• 848132-03-6 bauhinol D 
• 162411-67-8 2-methyl-5-phenethylbenzene-1,3-diol 
• 70610-11-6 3,5-dihydroxy-4-(3-methyl-2-butenyl)-bibenzyl 
• 73436-03-0 2-geranyl-5-(2-phenylethyl)resorcin 
• 133156-38-4 1,3-Bis(methoxymethoxy)-2-geranyl-5-phenethylbenzol 
• 133156-37-3 1,3-Bis(methoxymethoxy)-2-(3-methyl-2-butenyl)-5-phenethylbenzol 

Relevant academic research and scientific papers

Efficient synthesis of bibenzyl derivatives bearing pyranyl moieties: First total synthesis of bauhinol D

An efficient and general synthesis of bibenzyl derivatives bearing pyranyl rings was achieved by ethylenediamine diacetate-catalyzed reactions of 3,5-dihydroxybibenzyl with αβ-unsaturated aldehydes in moderate yields. These reactions provided naturally occurring compounds 1 and 2 in single step reaction. As an application of this methodology, biologically interesting natural bauhinol D (8) was synthesized by a convergent sequence from readily available benzaldehyde and benzyl phosphonate.

Synthesis of bryophyte components 2. Syntheses of prenylated bibenzyl derivatives

Efficient and expeditious syntheses of the biologically active prenylated bibenzyl derivatives 1a-d are developed giving rise to their access on a preparative scale.